Document Detail


Noradrenergic function in panic disorder. Effects of intravenous clonidine pretreatment on lactate induced panic.
MedLine Citation:
PMID:  1737075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the role of noradrenergic stimulation during lactate-induced panic, ten patients with panic disorder who panicked during a standard sodium-lactate infusion underwent a repeat infusion following intravenous clonidine pretreatment. Although clonidine significantly lowered prelactate systolic blood pressure, the drug did not significantly lower prelactate anxiety levels, as reflected by the Acute Panic Inventory (API). Clonidine blocked lactate-induced panic in four of ten subjects, a significant effect. Clonidine treatment also significantly attenuated lactate-panic symptoms, as reflected by time to panic and API comparison between trials. Nevertheless, over half the subjects still panicked in response to lactate despite clonidine. This preliminary study suggests that reduction of central noradrenergic activity by clonidine, at least at the dosage levels employed in the current study, only partially attenuates panic response to lactate. Noradrenergic theories of panic may not therefore fully account for lactate panicogenesis.
Authors:
J D Coplan; M R Liebowitz; J M Gorman; A J Fyer; D J Dillon; R B Campeas; S O Davies; J Martinez; D F Klein
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  31     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-17     Completed Date:  1992-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-46     Citation Subset:  IM    
Affiliation:
New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, New York.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects
Clonidine / administration & dosage,  pharmacology*,  therapeutic use
Dose-Response Relationship, Drug
Female
Humans
Infusions, Intravenous
Lactates*
Lactic Acid
Male
Middle Aged
Panic Disorder / chemically induced*,  diagnosis,  prevention & control,  psychology
Personality Inventory
Grant Support
ID/Acronym/Agency:
MH-00416/MH/NIMH NIH HHS; MH-30906/MH/NIMH NIH HHS; T32-MH 18641/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Lactates; 4205-90-7/Clonidine; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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