Document Detail

Noradrenergic function in panic anxiety. Effects of yohimbine in healthy subjects and patients with agoraphobia and panic disorder.
MedLine Citation:
PMID:  6742977     Owner:  NLM     Status:  MEDLINE    
Yohimbine, an alpha 2-adrenergic receptor antagonist that increases noradrenergic function, was administered to 20 healthy subjects and 39 drug-free patients with agoraphobia and panic attacks. Following drug administration, changes in plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), BP, pulse rate, and subjective ratings of feelings and somatic symptoms were examined during a four-hour period. Yohimbine produced significantly greater increases in patient-rated anxiety, nervousness, palpitations, hot and cold flashes, restlessness, tremors, piloerection, and sitting systolic BP in the total patient group compared with healthy subjects. There were significant correlations between the yohimbine-induced rise in plasma MHPG level and patient-rated anxiety and nervousness and the frequency of reported panic attacks. Patients experiencing frequent panic attacks (greater than 2.5 per week) had a significantly greater plasma MHPG response to yohimbine than the healthy subjects and patients having less frequent panic attacks. These observations support a hypothesis of increased sensitivity to augmented noradrenergic function in anxiety states associated with panic, and they suggest that impaired presynaptic noradrenergic neuronal regulation may exist in patients with frequent panic attacks.
D S Charney; G R Heninger; A Breier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  41     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-08-21     Completed Date:  1984-08-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  751-63     Citation Subset:  AIM; IM    
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MeSH Terms
Agoraphobia / physiopathology
Anxiety Disorders / blood,  physiopathology*,  psychology
Blood Pressure / drug effects
Fear* / drug effects
Heart Rate / drug effects
Methoxyhydroxyphenylglycol / blood
Middle Aged
Norepinephrine / physiology*
Panic* / drug effects
Pulse / drug effects
Receptors, Adrenergic / drug effects,  physiology*
Yohimbine / pharmacology
Grant Support
Reg. No./Substance:
0/Receptors, Adrenergic; 146-48-5/Yohimbine; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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