Document Detail


Noradrenergic but not cholinergic modulation of olfactory bulb during processing of near threshold concentration stimuli.
MedLine Citation:
PMID:  23025834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuromodulatory systems such as noradrenaline (NE), acetylcholine (ACh), and serotonin (5HT) serve important functions in sensory perception. We use the olfactory bulb (OB) as a model system to study the roles of individual neuromodulators in sensory perception. Using a spontaneous, nonreward motivated detection task, as well as a reward-motivated task, we show that rats can easily respond to odorants at very low concentrations when motivated to do so in a food-rewarded task, despite not showing spontaneous responses to these low concentration odorants. Using the same tasks paired with local bulbar infusions of noradrenergic and cholinergic drugs, we then show that rats engage their noradrenergic, but not their cholinergic system, to better respond to near threshold odorants. These results suggest that while cholinergic modulation of OB function is mostly important for odor decorrelation and discrimination, noradrenergic modulation is important for signal-to-noise modulation.
Authors:
Olga Escanilla; Sam Alperin; Monica Youssef; Matthew Ennis; Christiane Linster
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  126     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-03-14     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-8     Citation Subset:  IM    
Copyright Information:
PsycINFO Database Record (c) 2012 APA, all rights reserved.
Affiliation:
Computational Physiology Lab, Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 13068, USA.
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MeSH Terms
Descriptor/Qualifier:
Aconitine / analogs & derivatives,  pharmacology
Adrenergic alpha-Antagonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Alprenolol / pharmacology
Animals
Carbachol / pharmacology*
Choice Behavior / drug effects
Cholinergic Agonists / pharmacology*
Habituation, Psychophysiologic / drug effects
Male
Muscarinic Antagonists / pharmacology
Nicotinic Antagonists / pharmacology
Norepinephrine / pharmacology*
Odors*
Olfactory Bulb / drug effects*
Olfactory Perception / drug effects*
Phentolamine / pharmacology
Rats
Rats, Sprague-Dawley
Scopolamine Hydrobromide / pharmacology
Sensory Thresholds / drug effects
Grant Support
ID/Acronym/Agency:
DC008702/DC/NIDCD NIH HHS; DC009948/DC/NIDCD NIH HHS; R01 DC008702/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Cholinergic Agonists; 0/Muscarinic Antagonists; 0/Nicotinic Antagonists; 13655-52-2/Alprenolol; 21019-30-7/methyllycaconitine; 302-27-2/Aconitine; 50-60-2/Phentolamine; 51-34-3/Scopolamine Hydrobromide; 51-41-2/Norepinephrine; 51-83-2/Carbachol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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