| Noradrenergic but not cholinergic modulation of olfactory bulb during processing of near threshold concentration stimuli. | |
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MedLine Citation:
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PMID: 23025834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuromodulatory systems such as noradrenaline (NE), acetylcholine (ACh), and serotonin (5HT) serve important functions in sensory perception. We use the olfactory bulb (OB) as a model system to study the roles of individual neuromodulators in sensory perception. Using a spontaneous, nonreward motivated detection task, as well as a reward-motivated task, we show that rats can easily respond to odorants at very low concentrations when motivated to do so in a food-rewarded task, despite not showing spontaneous responses to these low concentration odorants. Using the same tasks paired with local bulbar infusions of noradrenergic and cholinergic drugs, we then show that rats engage their noradrenergic, but not their cholinergic system, to better respond to near threshold odorants. These results suggest that while cholinergic modulation of OB function is mostly important for odor decorrelation and discrimination, noradrenergic modulation is important for signal-to-noise modulation. |
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Authors:
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Olga Escanilla; Sam Alperin; Monica Youssef; Matthew Ennis; Christiane Linster |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Behavioral neuroscience Volume: 126 ISSN: 1939-0084 ISO Abbreviation: Behav. Neurosci. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-02 Completed Date: 2013-03-14 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 720-8 Citation Subset: IM |
Copyright Information:
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PsycINFO Database Record (c) 2012 APA, all rights reserved. |
Affiliation:
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Computational Physiology Lab, Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 13068, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aconitine
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analogs & derivatives,
pharmacology Adrenergic alpha-Antagonists / pharmacology Adrenergic beta-Antagonists / pharmacology Alprenolol / pharmacology Animals Carbachol / pharmacology* Choice Behavior / drug effects Cholinergic Agonists / pharmacology* Habituation, Psychophysiologic / drug effects Male Muscarinic Antagonists / pharmacology Nicotinic Antagonists / pharmacology Norepinephrine / pharmacology* Odors* Olfactory Bulb / drug effects* Olfactory Perception / drug effects* Phentolamine / pharmacology Rats Rats, Sprague-Dawley Scopolamine Hydrobromide / pharmacology Sensory Thresholds / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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DC008702/DC/NIDCD NIH HHS; DC009948/DC/NIDCD NIH HHS; R01 DC008702/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Cholinergic Agonists; 0/Muscarinic Antagonists; 0/Nicotinic Antagonists; 13655-52-2/Alprenolol; 21019-30-7/methyllycaconitine; 302-27-2/Aconitine; 50-60-2/Phentolamine; 51-34-3/Scopolamine Hydrobromide; 51-41-2/Norepinephrine; 51-83-2/Carbachol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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