| Noradrenergic agonists and antagonists: effects on avoidance behaviour in rats. | |
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MedLine Citation:
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PMID: 6145294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of various agonists and antagonists of both alpha and beta adrenoceptors on the acquisition of avoidance behaviour were investigated in the rat. Clonidine, a selective agonist of alpha 2 adrenoceptors depressed avoidance acquisition whilst yohimbine, an antagonist of these receptors produced an opposite effect. Prazosin which showed postsynaptic alpha 1 adrenoceptor blocking activity reduced avoidance behaviour. A similar effect was produced by propranolol, a non-selective antagonist of beta adrenoceptors. On the other hand, salbutamol preferentially stimulating beta 2 adrenoceptors facilitated avoidance behaviour. In general, the results show a fairly good correlation between avoidance acquisition and efficacy of noradrenergic neurotransmission. |
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Authors:
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M Obersztyn; W Kostowski |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta physiologica Polonica Volume: 34 ISSN: 0044-6033 ISO Abbreviation: Acta Physiol Pol Publication Date: 1983 Jul-Aug |
Date Detail:
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Created Date: 1984-07-18 Completed Date: 1984-07-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985166R Medline TA: Acta Physiol Pol Country: POLAND |
Other Details:
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Languages: eng Pagination: 401-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Agonists
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pharmacology* Animals Avoidance Learning / drug effects*, physiology Brain / physiology* Male Norepinephrine / physiology* Rats Rats, Inbred Strains Receptors, Adrenergic / drug effects, physiology* Sympatholytics / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Agonists; 0/Receptors, Adrenergic; 0/Sympatholytics; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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