Document Detail


Noradrenaline: a circulating inhibitor of sodium transport.
MedLine Citation:
PMID:  6435758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leucocytes were isolated from venous blood of 11 normotensive volunteers with no family history of hypertension and the sodium efflux rate constants determined both alone and in the presence of increasing physiological concentrations of noradrenaline. There was a significant dose dependent reduction of total sodium efflux rate constant due to a reduction in ouabain sensitive sodium pump activity, glycoside insensitive efflux rate constants being unaffected. The magnitude of this effect was similar to the reduction in leucocyte sodium efflux rate constants observed in hypertensive patients (and their normotensive relatives). The noradrenaline induced depression of sodium pump activity was prevented by propranolol in a further seven experiments, suggesting that the effect was mediated by beta adrenoceptors. Catecholamines possibly functioning as circulating inhibitors of sodium transport may contribute to some of the disturbances in membrane electrolyte handling both in essential hypertension in man and in some experimental models of hypertension.
Authors:
A Riozzi; A M Heagerty; R F Bing; H Thurston; J D Swales
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  289     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-12-05     Completed Date:  1984-12-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1025-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Transport, Active / drug effects
Dose-Response Relationship, Drug
Female
Humans
Hypertension / blood*
Leukocytes / metabolism*
Male
Norepinephrine / pharmacology,  physiology*
Ouabain / pharmacology
Sodium / blood*
Chemical
Reg. No./Substance:
51-41-2/Norepinephrine; 630-60-4/Ouabain; 7440-23-5/Sodium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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