Document Detail

Noradrenaline: a circulating inhibitor of sodium transport.
MedLine Citation:
PMID:  6435758     Owner:  NLM     Status:  MEDLINE    
Leucocytes were isolated from venous blood of 11 normotensive volunteers with no family history of hypertension and the sodium efflux rate constants determined both alone and in the presence of increasing physiological concentrations of noradrenaline. There was a significant dose dependent reduction of total sodium efflux rate constant due to a reduction in ouabain sensitive sodium pump activity, glycoside insensitive efflux rate constants being unaffected. The magnitude of this effect was similar to the reduction in leucocyte sodium efflux rate constants observed in hypertensive patients (and their normotensive relatives). The noradrenaline induced depression of sodium pump activity was prevented by propranolol in a further seven experiments, suggesting that the effect was mediated by beta adrenoceptors. Catecholamines possibly functioning as circulating inhibitors of sodium transport may contribute to some of the disturbances in membrane electrolyte handling both in essential hypertension in man and in some experimental models of hypertension.
A Riozzi; A M Heagerty; R F Bing; H Thurston; J D Swales
Related Documents :
2650688 - Epidemiological and intervention studies on the effect of marine polyunsaturated fatty ...
6407598 - Effect of magnesium on blood pressure.
17897108 - Influence of sodium profile in preventing complications during hemodialysis.
11710758 - Dominant effect of supplemented-sucrose on the low protein diet-induced increase in blo...
1000408 - Neurofibrillary tangles in the dementia of "normal pressure" hydrocephalus.
24969228 - Autonomic dysfunction responses to head-up tilt in anorexia nervosa.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  289     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-12-05     Completed Date:  1984-12-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1025-7     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Transport, Active / drug effects
Dose-Response Relationship, Drug
Hypertension / blood*
Leukocytes / metabolism*
Norepinephrine / pharmacology,  physiology*
Ouabain / pharmacology
Sodium / blood*
Reg. No./Substance:
51-41-2/Norepinephrine; 630-60-4/Ouabain; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical implications of developments in in vitro fertilisation.
Next Document:  Trends in parasuicide and unemployment among men in Edinburgh, 1968-82.