Document Detail


Nonvisualization of an enlarged spleen on Ga-67 scintigraphy but demonstrated by CT after splenic irradiation.
MedLine Citation:
PMID:  3857140     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Presence of enlarged spleen using CT with absence of splenic visualization in Ga-67 citrate images in a patient with chronic myelogenous leukemia and splenomegaly after splenic irradiation was observed. Since Howell-Jolly bodies had not been identified in the peripheral circulation, the finding of splenic nonvisualization was explained by disassociated splenic functions, which are not tightly coupled, and some activities that can be suppressed by irradiation without impairing others. The Ga-67 splenic localization mechanism is probably more sensitive and liable to disruption by irradiation, and was independent of spleen size. Ga-67 scintigraphy and Tc-99m sulfur colloid liver-spleen scintigraphy are two organ function-dependent imaging procedures, while CT provides anatomic information.
Authors:
W J Shih; P A Domstad; F H DeLand; Y Maruyama
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  10     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-29     Completed Date:  1985-05-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  184-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Gallium Radioisotopes / diagnostic use*
Humans
Leukemia, Myeloid / radiotherapy
Male
Middle Aged
Spleen / radiation effects*
Splenomegaly / radiography,  radionuclide imaging*,  radiotherapy
Tomography, X-Ray Computed*
Chemical
Reg. No./Substance:
0/Gallium Radioisotopes

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