Document Detail

Nonvirionic inhibitor of DNA synthesis in human embryo fibroblast cell cultures infected with rubella virus.
MedLine Citation:
PMID:  1125108     Owner:  NLM     Status:  MEDLINE    
Human embryo fibroblast cell cultures (RU-I) infected with virulent and attentuated strains of rubella virus of treated with a cell extract form infected and from control cultures have been studies in respect of their mitotic activity by evaluating the (3-H) thymidine uptake by autoradiography. The results show the presence in infected cell cultures of a nonvirionic inhibitor of DNA synthesis, which is detectable in control cell cultures too, though to a lesser degree. The relation of this inhibitor to the chalone system is so far unclear. No effect of the extracts on human chromosome pattern was observed. Attempts of biochemical characterization by fractionation of 14-C-labeled extracts on polyacrylamide gel followed by autoradiography were unsuccessful.
G Gerna; A Favino; P Cereda; C Minoia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bollettino dell'Istituto sieroterapico milanese     Volume:  54     ISSN:  0021-2547     ISO Abbreviation:  Boll Ist Sieroter Milan     Publication Date:  1975  
Date Detail:
Created Date:  1975-08-08     Completed Date:  1975-08-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  17720040R     Medline TA:  Boll Ist Sieroter Milan     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
DNA / antagonists & inhibitors,  biosynthesis*
Embryo, Mammalian
Rubella virus*
Virus Cultivation
Reg. No./Substance:

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