Document Detail

Nonventilatory strategies for patients with life-threatening 2009 H1N1 influenza and severe respiratory failure.
MedLine Citation:
PMID:  20035216     Owner:  NLM     Status:  MEDLINE    
Severe respiratory failure (including acute lung injury and acute respiratory distress syndrome) caused by 2009 H1N1 influenza infection has been reported worldwide. Refractory hypoxemia is a common finding in these patients and can be challenging to manage. This review focuses on nonventilatory strategies in the advanced treatment of severe respiratory failure and refractory hypoxemia such as that seen in patients with severe acute respiratory distress syndrome attributable to 2009 H1N1 influenza. Specific modalities covered include conservative fluid management, prone positioning, inhaled nitric oxide, inhaled vasodilatory prostaglandins, and extracorporeal membrane oxygenation and life support. Pharmacologic strategies (including steroids) investigated for the treatment of severe respiratory failure are also reviewed.
Lena M Napolitano; Pauline K Park; Krishnan Raghavendran; Robert H Bartlett
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical care medicine     Volume:  38     ISSN:  1530-0293     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e74-90     Citation Subset:  AIM; IM    
Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
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MeSH Terms
Acute Lung Injury / etiology,  therapy*
Administration, Inhalation
Anoxia / etiology,  therapy
Extracorporeal Membrane Oxygenation
Fluid Therapy
Influenza A Virus, H1N1 Subtype*
Influenza, Human / complications*
Nitric Oxide / therapeutic use
Prone Position
Prostaglandins / therapeutic use
Respiratory Distress Syndrome, Adult / etiology,  therapy*
Reg. No./Substance:
0/Prostaglandins; 10102-43-9/Nitric Oxide

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