| Nonvasculitic autoimmune inflammatory meningoencephalitis. | |
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MedLine Citation:
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PMID: 15139593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caselli and colleagues described five cases with encephalopathy, progressive cognitive decline, ataxia, abnormal CSF studies and steroid responsiveness, and proposed the term non-vasculitic autoimmune inflammatory meningoencephalitis (NAIM). Many of these cases had brain biopsy showing mild leptomeningeal perivascular lymphocytic inflammation, however, none of the cases had a post-mortem. Nonvasculitic autoimmune mediated meningoencephalitis has been described in patients with Sjogren's syndrome, systemic lupus erythematosus and, more recently, with Hashimoto's disease. The present study is the first post-mortem report of a case with a clinical diagnosis of NAIM. Neuropathological examination revealed a panencephalitis with intact vessel walls. T and B immunostaining showed a mixture of T and B cells. The findings were not consistent with other reported findings in collagen vascular diseases including Sjogren's syndrome, CNS vasculitis or Hashimoto's encephalopathy. There was no evidence of neoplasia, bacteria, acid-fast bacilli, fungi or atypical infectious agents. This is the first post-mortem report of a case with a clinical diagnosis of NAIM and demonstrates a panencephalitis without evidence of a vasculitis. The pathology seems unique, however, Sjogren and Hashimoto's encephalopathy might be variants of NAIM. |
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Authors:
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Keith A Josephs; Frank A Rubino; Dennis W Dickson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Neuropathology : official journal of the Japanese Society of Neuropathology Volume: 24 ISSN: 0919-6544 ISO Abbreviation: Neuropathology Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-13 Completed Date: 2004-06-17 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9606526 Medline TA: Neuropathology Country: Australia |
Other Details:
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Languages: eng Pagination: 149-52 Citation Subset: IM |
Affiliation:
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Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Autoimmune Diseases / pathology* Autopsy Brain / blood supply, pathology* Diagnosis, Differential Fatal Outcome Female Humans Inflammation / pathology* Meningoencephalitis / pathology* |
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