Document Detail

Nonvalvular atrial fibrillation as a cause of fatal massive cerebral infarction in the elderly.
MedLine Citation:
PMID:  2595728     Owner:  NLM     Status:  MEDLINE    
By studying 3,408 consecutive autopsied elderly patients, we found that two thirds of the 132 massive cerebral infarctions (86) were embolic, of cardiac origin. Embolic infarction associated with nonvalvular atrial fibrillation was seen in 48 cases (36%), half due to the first stroke. Embolic infarction associated with heart disease other than nonvalvular atrial fibrillation was seen in 23 cases (17%), and that from nonbacterial thrombotic endocarditis was seen in 15 cases (11%). Thrombotic infarction or infarction of nonembolic cardiac origin was found in only 39 cases (30%). Of 56 patients with fatal massive cerebral infarction who died less than or equal to 2 weeks after their stroke, 25 (45%) had embolic strokes associated with nonvalvular atrial fibrillation. Our study shows that nonvalvular atrial fibrillation is a very important cause of fatal massive cerebral infarction in the elderly.
H Yamanouchi; M Tomonaga; H Shimada; S Matsushita; K Kuramoto; Y Toyokura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  20     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-19     Completed Date:  1990-01-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1653-6     Citation Subset:  IM    
Department of Neurology, Tokyo Metropolitan Geriatric Hospital, Japan.
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MeSH Terms
Aged, 80 and over
Atrial Fibrillation / complications*
Brain Ischemia / complications
Cerebral Infarction / etiology*,  mortality
Cerebrovascular Disorders / complications
Hypertension / complications
Intracranial Embolism and Thrombosis / complications
Middle Aged

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