| Nonuniformity of axial and circumferential remodeling of large coronary veins in response to ligation. | |
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MedLine Citation:
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PMID: 16299258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pressure-induced remodeling of coronary veins is important in coronary venous retroperfusion. Our hypothesis is that the response of the large coronary veins to pressure overload will depend on the degree of myocardial support. Eleven normal Yorkshire swine from either sex, weighing 31-39 kg, were studied. Five pigs underwent ligation of the left anterior descending (LAD) vein, and six served as sham-operated controls. The ligation of the coronary vein caused an increase in pressure intermediate to arterial and venous values. After 2 wk of ligation, the animals were euthanized and the coronary vessels were perfusion-fixed with glutaraldehyde. The LAD vein was sectioned, and detailed morphometric measurements were made along its length from the point of ligation near the base down to the apex of the heart. The structural remodeling of the vein was circumferentially nonuniform because the vein is partially embedded in the myocardium; it was also axially nonuniform because it is tethered to the myocardium to different degrees along its axial length. The wall area was significantly larger in the experimental group, whereas luminal area in the proximal LAD vein was significantly smaller in the same group compared with sham-operated controls. The wall thickness-to-radius ratio was also significantly larger in the experimental group in proportion to the increase in pressure. The major conclusion of this study is that the response of the vein depends on the local wall stress, which is, in part, determined by the surrounding tissue. Furthermore, the geometric remodeling of the coronary vein restores the circumferential stress to the homeostatic value. |
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Authors:
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Jenny Susana Choy; Quang Dang; Sabee Molloi; Ghassan S Kassab |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2005-11-18 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 290 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-15 Completed Date: 2006-05-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1558-65 Citation Subset: IM |
Affiliation:
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Dept. of Biomedical Engineering, University of California, Irvine, CA 92697-2715, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anatomy, Cross-Sectional Animals Anisotropy Coronary Disease / complications, pathology*, physiopathology Coronary Vessels / pathology*, physiopathology*, surgery Female Hypertension / complications, pathology*, physiopathology Ligation Male Swine Veins / pathology*, physiopathology*, surgery |
| Grant Support | |
ID/Acronym/Agency:
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2-R01-HL-05554-06/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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