| Nonuniform cardiac sympathetic nerve discharge: mechanism for coronary occlusion and digitalis-induced arrhythmia. | |
| | |
MedLine Citation:
|
PMID: 639225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study examined nonuniform postganglionic cardiac sympathetic neural discharge as a possible mechanism involved in the production of coronary occlusion or ouabain-induced arrhythmias. After acute occlusion of the left anterior descending coronary artery in 12 cats, anesthetized with alpha-chloralose and pretreated with atropine, arrhythmia occurred within 3 min in eight animals; three of these died in ventricular fibrillation. In recordings from 15 nerves in the eight animals with arrhythmia, spontaneous discharge increased in nine nerves, decreased in five nerves, and showed no change in one nerve. This nonuniform neural discharge was associated with the development of arrhythmia after occlusion. In four of the cats, neural discharge did not change within the first 3 min after coronary artery occlusion and arrhythmia did not occur. Development of ouabain-induced arrhythmia was accompanied by a nonuniform pattern in the neural discharge (13 cats). This discharge may alter ventricular excitation and conduction to produce arrhythmia. |
| | |
Authors:
|
C M Lathers; G J Kelliher; J Roberts; A B Beasley |
Related Documents
:
|
15500415 - A benefit-risk assessment of class iii antiarrhythmic agents. 8427175 - Influence of clinical and hemodynamic characteristics on signal-averaged electrocardiog... 22510795 - Midterm results of the "sandwich technique" via a right ventricle incision to repair po... 937905 - Treatment of recurrent symptomatic ventricular tachycardia. 22564805 - Rapid onset of fulminant myocarditis portends a favourable prognosis and the ability to... 1449095 - Treatment of chronic stable angina pectoris. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation Volume: 57 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1978 Jun |
Date Detail:
|
Created Date: 1978-06-28 Completed Date: 1978-06-28 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1058-65 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials Animals Arrhythmias, Cardiac / chemically induced* Arterial Occlusive Diseases / physiopathology* Blood Pressure / drug effects Cats Coronary Vessels / physiopathology* Digitalis* Heart / innervation* Heart Conduction System / physiopathology Heart Rate / drug effects Ouabain / pharmacology Plants, Medicinal* Plants, Toxic* Sympathetic Nervous System / physiopathology* Time Factors |
| Chemical | |
Reg. No./Substance:
|
630-60-4/Ouabain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lactic dehydrogenase isoenzyme determination in the diagnosis of acute myocardial infarction.
Next Document: Comparison of the electrocardiographic changes induced by maximam exercise testing with treadmill an...