Document Detail

Nonuniform cardiac sympathetic nerve discharge: mechanism for coronary occlusion and digitalis-induced arrhythmia.
MedLine Citation:
PMID:  639225     Owner:  NLM     Status:  MEDLINE    
This study examined nonuniform postganglionic cardiac sympathetic neural discharge as a possible mechanism involved in the production of coronary occlusion or ouabain-induced arrhythmias. After acute occlusion of the left anterior descending coronary artery in 12 cats, anesthetized with alpha-chloralose and pretreated with atropine, arrhythmia occurred within 3 min in eight animals; three of these died in ventricular fibrillation. In recordings from 15 nerves in the eight animals with arrhythmia, spontaneous discharge increased in nine nerves, decreased in five nerves, and showed no change in one nerve. This nonuniform neural discharge was associated with the development of arrhythmia after occlusion. In four of the cats, neural discharge did not change within the first 3 min after coronary artery occlusion and arrhythmia did not occur. Development of ouabain-induced arrhythmia was accompanied by a nonuniform pattern in the neural discharge (13 cats). This discharge may alter ventricular excitation and conduction to produce arrhythmia.
C M Lathers; G J Kelliher; J Roberts; A B Beasley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  57     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-06-28     Completed Date:  1978-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1058-65     Citation Subset:  AIM; IM    
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MeSH Terms
Action Potentials
Arrhythmias, Cardiac / chemically induced*
Arterial Occlusive Diseases / physiopathology*
Blood Pressure / drug effects
Coronary Vessels / physiopathology*
Heart / innervation*
Heart Conduction System / physiopathology
Heart Rate / drug effects
Ouabain / pharmacology
Plants, Medicinal*
Plants, Toxic*
Sympathetic Nervous System / physiopathology*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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