Document Detail

Nontuberculous mycobacterial infections in Chinese hematopoietic stem cell transplantation recipients.
MedLine Citation:
PMID:  13130319     Owner:  NLM     Status:  MEDLINE    
Between 1995 and 2002, nine cases of nontuberculous mycobacterium (NTM) were isolated from 462 allogeneic stem cell transplant (SCT) recipients (1.9%), and none from 139 autologous cases. They included three cases each of Mycobacterium fortuitum and M. chelonae, and single cases of M. scrofalaceum, M. gordonnae and M. avium complex. Seven cases were respiratory, including five cases requiring treatment, and two involved infected catheters and vascular conduits. Compared with nine cases of mycobacterium tuberculosis (MTB) isolated in the same period, NTM isolation occurred later after HSCT and involved more unrelated donors. Important risk factors for NTM infection included significant aGVHD (P=0.043), leukemia relapse (P=0.022), MUD and mismatch SCT (P<0.001) and existence of BO (P<0.001). Coinfection with aspergillus was common. Invasive NTM disease required prolonged antimicrobial treatment in five cases due to M. fortuitum and M. chelonae. With better MTB prophylaxis, intensive immunosuppression and better awareness, NTM has become an emerging threat in oriental allogeneic HSCT recipients. The cutoff between colonization and infection, and the threshold for starting treatment is unclear. NTM isolation is a marker for severe immunosuppression and poor prognosis. When there is doubt over species identity or extent of infection, broad-spectrum cover may be prudent.
W Y Au; V C C Cheng; P L Ho; K Y Yuen; I Hung; S Y Ma; A K W Lie; R Liang; Y L Kwong
Related Documents :
12960619 - A 50-year experience with bone graft epiphysiodesis in the treatment of slipped capital...
8919209 - Primary ciliary dyskinesia: ultrastructural defects and clinical features.
3855689 - A complex translocation in acute promyelocytic leukemia.
23799169 - Ethmoidal mucocele presenting as oculomotor nerve paralysis.
16271959 - Translocation (6;17)(q23;q11.2): a novel cytogenetic abnormality in congenital acute my...
15994049 - Nonfatal pulmonary trichoderma viride infection in an adult patient with acute myeloid ...
3457629 - Reactivity patterns of monoclonal antibodies positive on myelomonocytic leukemia cells ...
1895129 - Psychosis following temporal lobe surgery: a report of six cases.
25462549 - Internal jugular vein pyogenic capillary hemangioma: a case report.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  32     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-17     Completed Date:  2004-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  709-14     Citation Subset:  IM    
Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aspergillosis / etiology
Catheterization / adverse effects
China / epidemiology
Hematopoietic Stem Cell Transplantation / adverse effects*
Immunosuppression / adverse effects
Middle Aged
Mycobacterium Infections / etiology*,  microbiology
Respiratory Tract Infections / etiology,  microbiology
Retrospective Studies
Risk Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Low-dose short-course intravenous ganciclovir as pre-emptive therapy for CMV viremia post allo-PBSC ...
Next Document:  Total parenteral nutrition vs oral diet in autologous hematopoietic cell transplant recipients.