| Nontuberculous mycobacterial infections in Chinese hematopoietic stem cell transplantation recipients. | |
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MedLine Citation:
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PMID: 13130319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Between 1995 and 2002, nine cases of nontuberculous mycobacterium (NTM) were isolated from 462 allogeneic stem cell transplant (SCT) recipients (1.9%), and none from 139 autologous cases. They included three cases each of Mycobacterium fortuitum and M. chelonae, and single cases of M. scrofalaceum, M. gordonnae and M. avium complex. Seven cases were respiratory, including five cases requiring treatment, and two involved infected catheters and vascular conduits. Compared with nine cases of mycobacterium tuberculosis (MTB) isolated in the same period, NTM isolation occurred later after HSCT and involved more unrelated donors. Important risk factors for NTM infection included significant aGVHD (P=0.043), leukemia relapse (P=0.022), MUD and mismatch SCT (P<0.001) and existence of BO (P<0.001). Coinfection with aspergillus was common. Invasive NTM disease required prolonged antimicrobial treatment in five cases due to M. fortuitum and M. chelonae. With better MTB prophylaxis, intensive immunosuppression and better awareness, NTM has become an emerging threat in oriental allogeneic HSCT recipients. The cutoff between colonization and infection, and the threshold for starting treatment is unclear. NTM isolation is a marker for severe immunosuppression and poor prognosis. When there is doubt over species identity or extent of infection, broad-spectrum cover may be prudent. |
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Authors:
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W Y Au; V C C Cheng; P L Ho; K Y Yuen; I Hung; S Y Ma; A K W Lie; R Liang; Y L Kwong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bone marrow transplantation Volume: 32 ISSN: 0268-3369 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-17 Completed Date: 2004-06-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: England |
Other Details:
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Languages: eng Pagination: 709-14 Citation Subset: IM |
Affiliation:
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Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. auwing@hotmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspergillosis / etiology Catheterization / adverse effects China / epidemiology Female Hematopoietic Stem Cell Transplantation / adverse effects* Humans Immunosuppression / adverse effects Male Middle Aged Mycobacterium Infections / etiology*, microbiology Respiratory Tract Infections / etiology, microbiology Retrospective Studies Risk Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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