Document Detail

Nontraditional epidemiologic approaches in the analysis of gene-environment interaction: case-control studies with no controls!
MedLine Citation:
PMID:  8686689     Owner:  NLM     Status:  MEDLINE    
Although case-control studies are suitable for assessing gene-environment interactions, choosing appropriate control subjects is a valid concern in these studies. The authors review three nontraditional study designs that do not include a control group: 1) the case-only study, 2) the case-parental control study, and 3) the affected relative-pair method. In case-only studies, one can examine the association between an exposure and a genotype among case subjects only. Odds ratios are interpreted as a synergy index on a multiplicative scale, with independence assumed between the exposure and the genotype. In case-parental control studies, one can compare the genotypic distribution of case subjects with the expected distribution based on parental genotypes when there is no association between genotype and disease; the effect of a genotype can be stratified according to case subjects' exposure status. In affected relative-pair studies, the distribution of alleles identical by descent between pairs of affected relatives is compared with the expected distribution based on the absence of genetic linkage between the locus and the disease; the analysis can be stratified according to exposure status. Some or all of these methods have certain limitations, including linkage disequilibrium, confounding, assumptions of Mendelian transmission, an inability to measure exposure effects directly, and the use of a multiplicative scale to test for interaction. Nevertheless, they provide important tools to assess gene-environment interaction in disease etiology.
M J Khoury; W D Flanders
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of epidemiology     Volume:  144     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-08-21     Completed Date:  1996-08-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-13     Citation Subset:  IM    
Division of Birth Defects and Developmental Disabilities, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA.
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MeSH Terms
Case-Control Studies
Environmental Illness / epidemiology*,  genetics
Molecular Epidemiology / methods,  statistics & numerical data
Odds Ratio

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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