Document Detail


A Nontoxic Additive to Introduce X-Ray Contrast into Poly(Lactic Acid). Implications for Transient Medical Implants Such as Bioresorbable Coronary Vascular Scaffolds.
MedLine Citation:
PMID:  23950056     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bioresorbable coronary vascular scaffolds are about to revolutionize the landscape of interventional cardiology. These scaffolds, consisting of a poly(l-lactic acid) interior and a poly(d,l-lactic acid) surface coating, offer a genuine alternative for metallic coronary stents. Perhaps the only remaining drawback is that monitoring during implantation is limited to two X-ray contrast points. Here, a new approach to make the biodegradable scaffolds entirely radiopaque is explored. A new contrast agent is designed and synthesized. This compound is miscible with poly(d,l-lactic acid) matrix, and nontoxic to multiple cell types. Blends of poly(d,l-lactic acid) and the contrast agent are found to be hemocompatible, noncytotoxic, and radiopaque. The data show that it is possible to manufacture fully radiopaque bioresorbable coronary vascular scaffolds. Whole-stent X-ray visibility helps interventionalists ensure that the scaffold deploys completely. This important advantage may translate into improved safety, accuracy, and clinical performance of cardiac stents.
Authors:
Yujing Wang; Nynke M S van den Akker; Daniël G M Molin; Mick Gagliardi; Cees van der Marel; Martin Lutz; Menno L W Knetsch; Leo H Koole
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-15
Journal Detail:
Title:  Advanced healthcare materials     Volume:  -     ISSN:  2192-2640     ISO Abbreviation:  Adv Healthc Mater     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101581613     Medline TA:  Adv Healthc Mater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Faculty of Health, Medicine & Life Sciences Department of Biomedical Engineering/Biomaterials Science, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
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