| Nontargeted multicomponent analytical screening of plastic food contact materials using fast interpretation of deliverables via expert structure-activity relationship software. | |
| | |
MedLine Citation:
|
PMID: 19610389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Plastic packaging materials may release compounds into packed foodstuffs. To identify potential migrants of toxicological concern, resins, and multilayer foils (mainly polyethylene) intended for the production of food contact materials were extracted and analyzed by GC/mass spectrometry. To identify even compounds of low concentrations, AMDIS software was used and data evaluation was safeguarded by the Kovats retention index (RI) system. In this way, 46 compounds were identified as possible migrants. The expert structure-activity relationship software DEREK for Windows was utilized to evaluate all identified substances in terms of carcinogenicity, genotoxicity, thyroid toxicity, and miscellaneous endpoints for humans. Additionally, a literature search for these compounds was performed with Sci-Finder, but relevant data were missing for 28 substances. Seven compounds with adverse toxicological effects were identified. In addition, the RIs of 24 commercial additive standards, measured with a GC capillary column of intermediate polarity, are given. |
| | |
Authors:
|
Thorsten Rothenbacher; Wolfgang Schwack |
Related Documents
:
|
20640959 - Rapid multi-analyte quantification of benzophenone, 4-methylbenzophenone and related de... 18700199 - Avian migrants adjust migration in response to environmental conditions en route. 11962719 - Programme on the recyclability of food-packaging materials with respect to food safety ... 17687699 - Acrylamide in cereal and cereal products: a review on progress in level reduction. 9515049 - Sex-biased mortality in woodrats occurs in the absence of parental intervention 10552479 - Determination of the diglycidyl ether of bisphenol a and its derivatives in canned foods. 12448759 - Development and potential of starter lactobacilli resulting from exploration of the sou... 15618619 - Recognition of native and/or thermally induced denatured forms of the major food allerg... 15140109 - Adaptive divergence vs. environmental plasticity: tracing local genetic adaptation of m... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of AOAC International Volume: 92 ISSN: 1060-3271 ISO Abbreviation: J AOAC Int Publication Date: 2009 May-Jun |
Date Detail:
|
Created Date: 2009-07-20 Completed Date: 2009-08-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9215446 Medline TA: J AOAC Int Country: United States |
Other Details:
|
Languages: eng Pagination: 941-50 Citation Subset: IM |
Affiliation:
|
Chemisches und Veterinäruntersuchungsamt Stuttgart, Schaflandstrasse 3/2, 70736 Fellbach, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Food Contamination
/
analysis* Food Packaging* Gas Chromatography-Mass Spectrometry / methods* Plastics / adverse effects* Software Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
|
0/Plastics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analysis method study on 839 pesticide and chemical contaminant multiresidues in animal muscles by g...
Next Document: GC/MS screening method for phthalate esters in children's toys.