Document Detail


Nonsynonymous polymorphisms in FAT4 gene are associated with the risk of esophageal cancer in an eastern chinese population.
MedLine Citation:
PMID:  23319386     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
FAT4 plays a crucial role in carcinogenesis as a key component of the Hippo signaling pathway. We hypothesized that potential functional polymorphisms in the FAT4 gene may modify the risk of esophageal cancer. To test this hypothesis, we evaluated the association between four nonsynonymous polymorphisms (rs1039808, rs12508222, rs1567047 and rs1014867) in FAT4 and esophageal cancer risk in a case-control study of 2,139 esophageal cancer cases and 2,273 controls in a Chinese population. We found that the T allele of rs1014867 (Pro4972Ser) was significantly associated with a decreased risk of esophageal cancer (odds ratio [OR] = 0.77, 95% confidence interval [95%CI] = 0.66-0.90; P = 1.42×10(-3) ). We also observed a borderline significant association between rs1039808 (Ala807Val) and esophageal cancer risk (OR = 0.90, 95%CI = 0.82-1.00; P = 0.050), which was more prominent in non-drinkers (OR = 0.82, 95%CI = 0.71-0.94; P = 6.53×10(-3) ). Furthermore, we detected a significant interaction between rs1039808 genotypes and alcohol drinking on esophageal cancer risk (P = 0.013). These findings indicate that the nonsynonymous variants rs1014867 (Pro4972Ser) and rs1039808 (Ala807Val) of FAT4 may contribute to esophageal cancer susceptibility. © 2013 Wiley Periodicals, Inc.
Authors:
Jiangbo Du; Jian Ji; Yong Gao; Lin Xu; Jing Xu; Chen Zhu; Haiyong Gu; Jie Jiang; Huizhang Li; Hongxia Ma; Zhibin Hu; Guangfu Jin; Wei Guo; Xiaofei Chen; Hongbing Shen
Related Documents :
22938146 - Endoscopic hemostasis with endoscopic mucosal resection and multiple synchronous early ...
23057816 - Incidence of primary and second cancers in renal transplant recipients: a multicenter c...
24780536 - Diagnosing dying: an integrative literature review.
24583756 - Yield of screening colonoscopy in first-degree relatives of patients with serrated poly...
3934476 - Clinical effects of enteral and parenteral nutrition preceding cancer surgery.
20684186 - Capsule endoscopy: no longer limited to the small bowel.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 UICC.
Affiliation:
Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing, China; MOE Key Lab of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Association testing of the mitochondrial genome using pedigree data.
Next Document:  Development of a rapid and high-performance chemiluminescence immunoassay based on magnetic particle...