Document Detail

Nonsustained polymorphous ventricular tachycardia during amiodarone therapy for atrial fibrillation complicating cardiomyopathy. Management with intravenous magnesium sulfate.
MedLine Citation:
PMID:  9149614     Owner:  NLM     Status:  MEDLINE    
A case is presented in which amiodarone was administered to suppress paroxysmal atrial fibrillation in a patient with an idiopathic cardiomyopathy. Eleven days after initiation of therapy with amiodarone, the patient experienced syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia. The patient was hospitalized and treated with a bolus as well as continuous infusion of intravenous magnesium sulfate. When the infusion was transiently discontinued, recurrences of polymorphous ventricular tachycardia were noted. The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.
S L Winters; R G Sachs; J H Curwin
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Chest     Volume:  111     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-03     Completed Date:  1997-06-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1454-7     Citation Subset:  AIM; IM    
Morristown Memorial Hospital, NJ 07962-1956, USA.
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MeSH Terms
Amiodarone / adverse effects*
Anti-Arrhythmia Agents / administration & dosage,  adverse effects*,  therapeutic use
Atrial Fibrillation / complications,  drug therapy*
Cardiomyopathies / complications*
Infusions, Intravenous
Injections, Intravenous
Magnesium Sulfate / administration & dosage,  therapeutic use*
Syncope / chemically induced,  drug therapy
Tachycardia, Ventricular / chemically induced*,  drug therapy
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 7487-88-9/Magnesium Sulfate
Comment In:
Chest. 1998 Mar;113(3):848-9   [PMID:  9515876 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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