| Nonsurgical management of unruptured isthmic ectopic pregnancy: preliminary experience. | |
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MedLine Citation:
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PMID: 2898448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five unruptured isthmic tubal pregnancies diagnosed at laparoscopy were treated with either methotrexate/citrovorum factor rescue (MTX/CF) (n = 4) or observation alone (n = 1). Entry criteria required that the ectopic be fully visualized, no greater than 3 cm in diameter, with intact serosa, and without active bleeding. Treatment selection was based upon preoperative levels of beta-hCG with MTX/CF given to subjects exhibiting a plateaued or rising pattern and observation alone given those with falling levels. Subjects were followed with serial measurements of beta-hCG, complete blood counts, and liver function tests. In all subjects the ectopic pregnancy resolved without further surgery. Time to resolution (first day of treatment to undetectable beta-hCG) ranged from 12 to 55 days. Of the five subjects studied, follow-up hysterosalpingograms in four demonstrated tubal patency on the side of the ectopic gestation. |
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Authors:
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M V Sauer; M J Gorrill; I A Rodi; T R Yeko; L H Greenberg; J E Gunning; J E Buster |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of fertility Volume: 33 ISSN: 0020-725X ISO Abbreviation: Int. J. Fertil. Publication Date: 1988 Mar-Apr |
Date Detail:
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Created Date: 1988-08-11 Completed Date: 1988-08-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374717 Medline TA: Int J Fertil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 116-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Chorionic Gonadotropin / analysis Clinical Protocols / standards Drug Therapy, Combination Fallopian Tubes / surgery Female Humans Leucovorin / pharmacology, therapeutic use Methotrexate / pharmacology, therapeutic use Oviducts / drug effects Pregnancy Pregnancy, Ectopic / drug therapy*, surgery |
| Grant Support | |
ID/Acronym/Agency:
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RR00425/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 58-05-9/Leucovorin; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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