| Nonsurgical management of renovascular hypertension in the neonate. | |
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MedLine Citation:
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PMID: 683786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over an 18-month period nine infants in a neonatal intensive care unit developed hypertension (blood pressure, 115/88 to 280/140 mm Hg) at 2 to 45 days of age. Eight of the nine infants had indwelling umbilical artery catheters prior to onset of hypertension; six of the nine infants had evidence of a patent ductus arteriosus. Peripheral plasma renin activity was greater than 300 ng/ml/3 hr in six of eight infants. Angiograms were abnormal in six of seven infants and computerized renal scans were abnormal in all nine infants. One infant had congenital renal artery stenosis. Eight of nine infants had evidence of unilateral or bilateral renal artery thrombi which were felt to have emanated from an umbilical artery catheter or a ductus arteriosus. Hypertension in all infants was successfully controlled medically (follow-up of 3 to 27 months; mean, 14.4 months). Blood pressures remained normal when medication was discontinued. In our experience, neonatal renovascular hypertension is no longer uncommon, responds to aggressive medical management, and rarely requires early nephrectomy. Neonatal renovascular hypertension was usually associated with umbilical artery catheters positioned above the level of the renal arteries. |
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Authors:
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R D Adelman; D Merten; J Vogel; B W Goetzman; R P Wennberg |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatrics Volume: 62 ISSN: 0031-4005 ISO Abbreviation: Pediatrics Publication Date: 1978 Jul |
Date Detail:
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Created Date: 1978-10-27 Completed Date: 1978-10-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 71-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / therapeutic use* Diazoxide / therapeutic use Diuretics / therapeutic use Female Humans Hydralazine / therapeutic use Hypertension, Renal / drug therapy* Infant, Newborn Infant, Newborn, Diseases / drug therapy* Male Methyldopa / therapeutic use Pregnancy Propranolol / therapeutic use Renin / blood |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Diuretics; 364-98-7/Diazoxide; 525-66-6/Propranolol; 555-30-6/Methyldopa; 86-54-4/Hydralazine; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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