Document Detail

Nonsteroidal antiinflammatory drugs and certain rare, serious adverse events: a cohort study.
MedLine Citation:
PMID:  8321735     Owner:  NLM     Status:  MEDLINE    
We performed a population-based study of over 100,000 users of diclofenac, naproxen, or piroxicam to identify cases of important blood, skin, central nervous system, kidney, pancreas, or pulmonary disorders caused by these drugs. In three cases a causal relation seemed likely; one of hemolytic anemia attributed to diclofenac, one of neutropenia attributed to naproxen, and one of pancreatitis attributed to piroxicam. In 13 additional cases a causal connection seemed unlikely but could not be fully ruled out. We conclude that such illnesses are uncommonly caused by the three agents studied.
H Jick; L E Derby; L A García Rodríguez; S S Jick; A D Dean
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacotherapy     Volume:  13     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:    1993 May-Jun
Date Detail:
Created Date:  1993-08-05     Completed Date:  1993-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  212-7     Citation Subset:  IM    
Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, MA 02173-5207.
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MeSH Terms
Aged, 80 and over
Anemia, Hemolytic / chemically induced*
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Cohort Studies
Diclofenac / adverse effects
Naproxen / adverse effects
Neutropenia / chemically induced*
Pancreatitis / chemically induced*
Piroxicam / adverse effects
Thrombocytopenia / chemically induced*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 15307-86-5/Diclofenac; 22204-53-1/Naproxen; 36322-90-4/Piroxicam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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