| Nonsteroidal anti-inflammatory drugs and cancer prevention. | |
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MedLine Citation:
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PMID: 10774479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, appear to have clinically significant anticarcinogenic effects in the gastrointestinal tract. Epidemiological data indicate that use of these drugs is inversely associated with the risk of sporadic colorectal cancer, and clinical trials among patients with familial polyposis coli show that NSAIDs can lead to the regression of large bowel adenomas. Animal studies have reported a similar efficacy of NSAIDs against experimental carcinogenesis. A consistent pattern in this research is that continued long-term use of NSAIDs is required for an anticancer effect--up to 15 or 20 years before a reduced risk of colorectal cancer appears. Epidemiological data also suggest possible protective effects in the stomach and esophagus. The mechanisms underlying any chemopreventive effect of NSAIDs are not clear. Inhibition of cyclooxygenase is one possibility, but pathways independent of cyclooxygenase and prostaglandins are also possible. |
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Authors:
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J A Baron; R S Sandler |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annual review of medicine Volume: 51 ISSN: 0066-4219 ISO Abbreviation: Annu. Rev. Med. Publication Date: 2000 |
Date Detail:
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Created Date: 2000-05-25 Completed Date: 2000-05-25 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 2985151R Medline TA: Annu Rev Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 511-23 Citation Subset: IM |
Affiliation:
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Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. John.A.Baron@Dartmouth.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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complications Adenomatous Polyposis Coli / complications Anti-Inflammatory Agents, Non-Steroidal / therapeutic use* Colorectal Neoplasms / etiology, prevention & control* Humans |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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