| Nonsteroidal antiinflammatory drugs in late pregnancy and persistent pulmonary hypertension of the newborn. | |
| | |
MedLine Citation:
|
PMID: 23209104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Persistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome of late-preterm and full-term infants associated with failure of the normal fetal-to-neonatal circulatory transition. This study was designed to test the hypothesis that risk for PPHN is increased after antenatal exposure to nonsteroidal antiinflammatory drugs (NSAIDs), with particular emphasis on late gestational exposures. METHODS: Between 1998 and 2003, we interviewed 377 women whose infants had PPHN and 836 control mothers of infants matched to cases by hospital and birth date. Interviews captured information on prescription and over-the-counter medication use in pregnancy as well as a variety of potential confounding factors. Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for third-trimester maternal NSAID use were estimated by using multivariate conditional logistic regression. RESULTS: During the third trimester of gestation, 33 infants (8.8%) with PPHN were exposed to any NSAID compared with 80 (9.6%) controls (OR 0.8; 95% CI 0.5-1.3). We observed an elevated OR for PPHN risk among infants whose mothers consumed aspirin during the third-trimester; however, the lower 95% CI included the null. Neither nonaspirin NSAIDs at any time during pregnancy nor ibuprofen use during the third trimester was associated with an elevated risk of PPHN. Similarly, no association was observed between a mother's third-trimester acetaminophen use and the occurrence of PPHN in her newborn. CONCLUSIONS: This large multicenter epidemiologic study of PPHN risk revealed no evidence to support the hypothesis that maternal consumption during pregnancy of NSAIDs overall or ibuprofen in particular is associated with PPHN risk. |
| | |
Authors:
|
Linda J Van Marter; Sonia Hernandez-Diaz; Martha M Werler; Carol Louik; Allen A Mitchell |
Related Documents
:
|
7078244 - Congenital funnel-shaped tracheal stenosis: an asymptomatic lethal anomaly of early inf... 1479504 - Postobstructive enteropathy in infants with transient enterostomy: its consequences on ... 1873714 - Success and failure with neonatal tracheo-oesophageal anomalies. 10466604 - Ontogeny of interstitial cells of cajal in the human intestine. 9736874 - Increasing social variation in birth outcomes in the czech republic after 1989. 18772364 - Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mou... |
Publication Detail:
|
Type: Case Reports; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Review Date: 2012-12-03 |
Journal Detail:
|
Title: Pediatrics Volume: 131 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-01-02 Completed Date: 2013-02-22 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
|
Languages: eng Pagination: 79-87 Citation Subset: AIM; IM |
Affiliation:
|
Boston Children's Hospital, Boston, Massachusetts 02115, USA. linda.vanmarter@childrens.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*, adverse effects Case-Control Studies Female Humans Hypertension, Pulmonary / chemically induced, diagnosis*, epidemiology Infant, Newborn Male Maternal-Fetal Exchange / drug effects*, physiology Pregnancy Pregnancy Trimester, Third / drug effects*, physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
HL58763/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents, Non-Steroidal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Retention and research use of residual newborn screening bloodspots.
Next Document: Reducing the Blood Culture Contamination Rate in a Pediatric Emergency Department and Subsequent Cos...