Document Detail

Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole.
MedLine Citation:
PMID:  306577     Owner:  NLM     Status:  MEDLINE    
To assess the cause of nonspecific vaginitis, we performed a prospective case-control study of vaginal flora and a randomized unblinded trial of different therapies. Haemophilus vaginalis was isolated from 17 to 18 women with signs of vaginitis but only one of 18 normal matched controls (P less than 0.002). The concentration of anaerobic bacteria in vaginal washings also was increased in patients. Clinical improvement and eradication of H. vaginalis occurred in one of seven patients given sulfonamide vaginal cream, two of 15 given oral doxycycline, nine of 27 given oral ampicillin, and 80 of 81 given oral metronidazole. On the seventh day of therapy signs of nonspecific vaginitis persisted in 31 of 31 with, and in two of 92 without, persistent H. vaginalis infection (P less than 0.001). These data suggest the causal role of H. vaginalis in nonspecific vaginitis, possibly in concert with vaginal anaerobes. The widespread use of sulfonamide creams is inappropriate. Metronidazole is effective, but its efficacy must be weighed against its possible toxicity.
T A Pheifer; P S Forsyth; M A Durfee; H M Pollock; K K Holmes
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  298     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1429-34     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Ampicillin / administration & dosage,  therapeutic use
Doxycycline / administration & dosage,  therapeutic use
Gardnerella vaginalis / drug effects,  isolation & purification
Haemophilus Infections / drug therapy*
Metronidazole / administration & dosage,  pharmacology,  therapeutic use
Prospective Studies
Sulfonamides / administration & dosage,  therapeutic use
Vagina / microbiology
Vaginal Creams, Foams, and Jellies
Vaginitis / drug therapy,  etiology*,  microbiology
Reg. No./Substance:
0/Sulfonamides; 0/Vaginal Creams, Foams, and Jellies; 443-48-1/Metronidazole; 564-25-0/Doxycycline; 69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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