Document Detail

Nonspecific esophageal motility disorders may be an early stage of a specific disorder, particularly achalasia.
MedLine Citation:
PMID:  19302217     Owner:  NLM     Status:  MEDLINE    
The clinical significance of nonspecific esophageal motility disorder (NEMD) is unclear. Our aim was to investigate the natural history of NEMD. All manometries performed at Meir Hospital from 1997 to 2004 and diagnosed as NEMD were reviewed. Manometric criteria for NEMD included either low-amplitude peristalsis, nonprogression of peristalsis, prolonged retrograde or triple-peaked waves, or incomplete relaxation of the lower sphincter. Patients determined to have NEMD were contacted and asked to complete a questionnaire and undergo a second manometry. NEMD had been diagnosed in 137 patients. Upon review of manometry results, 65 patients were eligible for the study (36 men and 29 women). The other 72 patients did not have NEMD when we reviewed their manometry tracing, applying strict criteria as specified in Table 1. The average age was 64 +/- 16 years (range 24-83 years). The average follow-up period was 7 +/- 2 years. All 65 patients were symptomatic at their initial prestudy visit. By the second visit, symptoms had resolved in 33 (51%) patients and improved in 13 (19%). Dysphagia, chest pain, and food regurgitation had improved, whereas heartburn and respiratory symptoms had not. Of 37 patients with triple-peaked waves, only 11 (30%) had improved clinically. Of the 65 study patients, 17 (26%) had a second manometry during the study, which was normal in 2 (12%), unchanged in 11 (69%), and revealed achalasia in 4 (23%), representing 6% of all study patients. NEMD is generally a benign disorder that improves clinically in most cases. Nevertheless, in about 6% of patients, NEMD may evolve into achalasia.
T Naftali; T Levit; I Pomeranz; F S Benjaminov; F M Konikoff
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Publication Detail:
Type:  Journal Article     Date:  2009-03-17
Journal Detail:
Title:  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E     Volume:  22     ISSN:  1442-2050     ISO Abbreviation:  Dis. Esophagus     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-07     Completed Date:  2010-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809160     Medline TA:  Dis Esophagus     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  611-5     Citation Subset:  IM    
Department of Gastroenterology and Hepatology, Meir Medical Center, Kfar Saba, Israel.
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MeSH Terms
Aged, 80 and over
Disease Progression
Esophageal Achalasia / diagnosis
Esophageal Motility Disorders / diagnosis*
Middle Aged
Retrospective Studies
Young Adult

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