| Nonshivering thermogenesis and cold resistance in rats under severe cold conditions. | |
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MedLine Citation:
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PMID: 1150558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Following either chronic exposure to 6 degrees C, or outdoor winter exposure, or chronic treatment with tyramine rats were exposed to -40 degrees C and their oxygen consumption and colonic temperature monitored. Fall in body temperature with time of exposure followed a sigmoid curve which had an inflection point around 32.9 degrees C. Both the time required for body temperature to reach this point and hypothermic resistance defined as the total O2 consumed up to the inflection time were useful indices of resistance to severe cold; Three days before the cold tests, capacity for norepinephrine-induced nonshivering thermogenesis was measured in all animals by examination of their metabolic response to tyraminemthe magnitude of response to tyramine correlated well with hypothermic resistance only for those rats chroncally treated with tyramine. It is concluded that it is impossible to predict with any reasonable degree of confidence the cold resistance of a rat from its tyramine response. In cold-acclimated rats, factors in addition to norepinephrine sensitivity are significantly involved in cold resistance and deserve further studies. |
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Authors:
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O Héroux; E Pagé; J Leblanc; J Leduc; R Gilbert; A Villemaire; P Rivest |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology Volume: 38 ISSN: 0021-8987 ISO Abbreviation: J Appl Physiol Publication Date: 1975 Mar |
Date Detail:
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Created Date: 1975-10-28 Completed Date: 1975-10-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376576 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 436-42 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization* Animals Body Temperature Body Temperature Regulation* Cold Temperature* Male Norepinephrine / pharmacology Oxygen Consumption Rats / physiology* Time Factors Tyramine / pharmacology |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-67-2/Tyramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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