| Nonselective beta-adrenergic blockade with carvedilol does not hinder the benefits of exercise training in patients with congestive heart failure. | |
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MedLine Citation:
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PMID: 9107160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Long-term beta-adrenergic blockade does not appear to be associated with drug-induced training in patients with congestive heart failure (CHF); whether exercise training can increase peak aerobic capacity in patients with CHF who are treated with beta-adrenergic blockers is currently unknown. METHODS AND RESULTS: We studied 23 patients with CHF who were treated with carvedilol or propranolol in addition to ACE inhibitors, furosemide, and digoxin. Of the patients treated with carvedilol, 8 underwent exercise training and 8 remained sedentary. All 7 patients treated with propranolol underwent exercise training. Peak oxygen consumption (mL.kg-1.min-1) was serially measured in trained and sedentary patients. Peak reactive hyperemia (mL.min-1.100 mL-1) was determined in the calf and forearm immediately before and after 12 weeks of training. The peak oxygen consumption of trained patients treated with either carvedilol or propranolol increased from 12.9 +/- 1.4 to 16.0 +/- 1.6 (P < .001) and 12.4 +/- 1.0 to 15.7 +/- 0.9 (P < .001) mL.kg-1.min-1, respectively, whereas it did not change in the sedentary patients. Peak reactive hyperemia increased significantly in the calves but not the forearms of trained patients. CONCLUSIONS: Long-term, nonselective beta-adrenergic blockade with carvedilol or propranolol does not prevent patients with CHF from deriving systemic and regional benefits from physical training. |
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Authors:
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L Demopoulos; M Yeh; M Gentilucci; M Testa; R Bijou; S D Katz; D Mancini; M Jones; T H LeJemtel |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Circulation Volume: 95 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-05-13 Completed Date: 1997-05-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1764-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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drug effects* Adrenergic beta-Antagonists / administration & dosage, adverse effects*, pharmacology, therapeutic use Aerobiosis Aged Angiotensin-Converting Enzyme Inhibitors / administration & dosage, therapeutic use Carbazoles / administration & dosage, adverse effects*, pharmacology, therapeutic use Cardiotonic Agents / administration & dosage, therapeutic use Digoxin / administration & dosage, therapeutic use Diuretics / administration & dosage, therapeutic use Drug Therapy, Combination Exercise Therapy* Female Forearm / blood supply Furosemide / administration & dosage, therapeutic use Heart / drug effects*, physiopathology Heart Failure / drug therapy*, rehabilitation Humans Hyperemia / etiology Leg / blood supply Male Middle Aged Oxygen Consumption / drug effects* Propanolamines / administration & dosage, adverse effects*, pharmacology, therapeutic use Propranolol / administration & dosage, pharmacology, therapeutic use Receptors, Adrenergic, beta / physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Carbazoles; 0/Cardiotonic Agents; 0/Diuretics; 0/Propanolamines; 0/Receptors, Adrenergic, beta; 20830-75-5/Digoxin; 525-66-6/Propranolol; 54-31-9/Furosemide; 72956-09-3/carvedilol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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