Document Detail

Nonsecretory multiple myeloma with amyloidosis. A case report and review of the literature.
MedLine Citation:
PMID:  15517373     Owner:  NLM     Status:  MEDLINE    
We report a case concerning a 49-year-old female patient with thoracic pain. X-rays showed a single osteolytic lesion on the right seventh rib. The excision of the rib disclosed a plasmocytic plasmocytoma with extensive amyloidosis. Serum and urine protein electrophoresis were both negative for monoclonal gammopathy. Bone marrow biopsy showed that 80% of the marrow had been replaced by plasma cells. A diagnosis of nonsecretory multiple myeloma was made. Immunohistochemistry revealed amyloid light (AL) amyloidosis of kappa-light chain origin. The relationship between nonsecretory multiple myeloma and amyloidosis is discussed.
Evariste Gafumbegete; Susann Richter; Ludwig Jonas; Horst Nizze; Josef Makovitzky
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2004-07-29
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  445     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-01     Completed Date:  2005-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  531-6     Citation Subset:  IM    
Department of Pathology, University of Rostock, Germany.
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MeSH Terms
Amyloid / analysis
Amyloidosis / metabolism*,  pathology
Blood Protein Electrophoresis
Immunoglobulins / analysis
Microscopy, Electron
Middle Aged
Multiple Myeloma / metabolism*,  ultrastructure
Reg. No./Substance:
0/Amyloid; 0/Immunoglobulins

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