Document Detail

Nonresonant MALDI of oligonucleotides: mechanism of ion desorption.
MedLine Citation:
PMID:  11248897     Owner:  NLM     Status:  MEDLINE    
Oligonucleotide ions have been detected using matrix-assisted laser desorption/ionization (MALDI) under nonresonant laser irradiation of the sample. When mass resolution was not limited by adduct attachment to the analyte ions, the nonresonant MALDI spectra demonstrated better resolution than the spectra acquired with resonant ultraviolet irradiation. We found that preparation of thin-film samples on absorbing substrate surfaces was critical for the success of NR-MALDI. The possible acoustic mechanisms of ion formation and desorption are discussed.
V V Golovlev; S H Lee; S L Allman; N I Taranenko; N R Isola; C H Chen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Analytical chemistry     Volume:  73     ISSN:  0003-2700     ISO Abbreviation:  Anal. Chem.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-15     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  809-12     Citation Subset:  IM    
Oak Ridge National Laboratory, Tennessee 37831-6378, USA.
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MeSH Terms
Oligonucleotides / analysis*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Spectrophotometry, Ultraviolet
Reg. No./Substance:

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