Document Detail


Nonprecipitating anti-La(SS-B) autoantibodies in primary Sjögren's syndrome.
MedLine Citation:
PMID:  8635291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anti-La(SS-B) precipitin-negative sera show a restricted epitope recognition and can be easily overlooked in routine laboratory testing. We have therefore determined the prevalence of nonprecipitating anti-La(SS-B) antibodies in patients with primary Sjögren's syndrome and studied their clinical and immunological associations. Clinical details were obtained from 68 patients with primary Sjögren's syndrome, and serum samples were examined by enzyme-linked immunosorbent assay using purified recombinant La, 60-kDa Ro, and 52-kDa Ro proteins and by counterimmunoelectrophoresis. Thirteen patients (19%) were identified with anti-La antibodies which were nonprecipitating. These patients had similar clinical findings to other groups of patients with Sjogren's syndrome, but had significantly lower rheumatoid factor and serum IgG levels than patients with anti-La precipitins. None of the patients with nonprecipitating anti-La antibodies had previously contained anti-La precipitins in their sera. Furthermore, they tended to have lower levels of antibodies directed against denatured 60-kDa Ro (but not 52-kDa Ro) compared with anti-La precipitin-positive patients. Patients with Sjögren's syndrome associated with nonprecipitating anti-La antibodies represent a stable serological and clinical subset in which there appears to be limited diversification of the autoimmune response to the Ro60 and La proteins of the Ro/La ribonucleoprotein.
Authors:
R G Beer; M Rischmueller; T Coates; A W Purcell; C L Keech; J McCluskey; T P Gordon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical immunology and immunopathology     Volume:  79     ISSN:  0090-1229     ISO Abbreviation:  Clin. Immunol. Immunopathol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-07-10     Completed Date:  1996-07-10     Revised Date:  2007-05-11    
Medline Journal Info:
Nlm Unique ID:  0356637     Medline TA:  Clin Immunol Immunopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  314-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Immunology, Flinders Medical Centre, South Australia, Australia.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Antinuclear / immunology*
Autoantigens / immunology*
Female
Humans
Male
Middle Aged
Molecular Weight
RNA, Small Cytoplasmic*
Ribonucleoproteins / immunology*
Sjogren's Syndrome / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Autoantigens; 0/RNA, Small Cytoplasmic; 0/Ribonucleoproteins; 0/SS-A antigen; 0/SS-B antibodies; 0/SS-B antigen; 0/TROVE2 protein, human

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