Document Detail

Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion.
MedLine Citation:
PMID:  22818543     Owner:  NLM     Status:  MEDLINE    
The development of anemia after birth in very premature, critically ill newborn infants is a universal well-described phenomenon. Although preventing anemia in this population, along with efforts to establish optimal red blood cell (RBC) transfusion and pharmacologic therapy continue to be actively investigated, the present review focuses exclusively on nonpharmacological approaches to the prevention and treatment of neonatal anemia. We begin with an overview of topics relevant to nonpharmacological techniques. These topics include neonatal and fetoplacental hemoglobin levels and blood volumes, clinical and laboratory practices applied in critically ill neonates, and current RBC transfusion practice guidelines. This is followed by a discussion of the most effective and promising nonpharmacological blood conservation strategies and techniques. Fortunately, many of these techniques are feasible in most neonatal intensive care units. When applied together, these techniques are more effective than existing pharmacotherapies in significantly decreasing neonatal RBC transfusions. They include increasing hemoglobin endowment and circulating blood volume at birth; removing less blood for laboratory testing; and optimizing nutrition.
Patrick D Carroll; John A Widness
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  36     ISSN:  1558-075X     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-23     Completed Date:  2012-12-07     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Women and Newborns Program, Intermountain Healthcare, Division of Neonatology, Dixie Regional Medical Center, St George, UT 84770, USA.
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MeSH Terms
Anemia, Neonatal / prevention & control*,  therapy*
Blood Volume*
Bloodless Medical and Surgical Procedures / methods*
Critical Illness / therapy
Erythrocyte Indices
Erythrocyte Transfusion / methods
Fetal Blood
Infant, Extremely Premature / blood
Infant, Newborn
Infant, Premature / blood
Nutritional Support / methods
Phlebotomy / adverse effects
Grant Support
Reg. No./Substance:

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