Document Detail

Nonphagocytic dendritic cells are effective accessory cells for anti-mycobacterial responses in vitro.
MedLine Citation:
PMID:  3918113     Owner:  NLM     Status:  MEDLINE    
The accessory cell requirements for a given T cell response may be examined in vitro by using highly purified lymph node T cells. We have examined the capacity of different antigen-presenting cells to stimulate proliferation of Mycobacterium tuberculosis-primed T cells when the antigenic challenge is either soluble or particulate in nature. By titrations of cell number and antigen concentration, it was shown that dendritic cells are not only extremely efficient at presenting soluble mycobacterial antigen compared with various macrophage populations, but also that they are capable of presenting whole mycobacteria. Because phagocytosis of mycobacteria does not occur with these cells, we suggest that processing of antigen by dendritic cells may be initiated at the plasma membrane. Because macrophages are not essential for this in vitro response, a role for dendritic cells in antibacterial immunity in vivo is implicated.
P M Kaye; B M Chain; M Feldmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  134     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-03-20     Completed Date:  1985-03-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1930-4     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Bacterial / biosynthesis*
Antigen-Presenting Cells / immunology*
Antigens, Bacterial / immunology
Dose-Response Relationship, Immunologic
Macrophages / immunology
Mice, Inbred CBA
Mycobacterium tuberculosis / immunology*
Spleen / cytology*
Tuberculin / immunology
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Tuberculin

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