| Nonparametric estimation of duration of accrual and total study length for clinical trials. | |
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MedLine Citation:
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PMID: 3427175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nonparametric estimates for all possible values of accrual duration and total study length required to achieve a specified power and level of significance are given assuming a proportional hazards model comparing two treatment groups. Based on data from a previous representative clinical trial, the nonparametric maximum likelihood estimate of total study length and its asymptotic distribution are derived as functions of accrual duration. An example using this technique is given for designing a clinical trial comparing two adjuvant chemotherapy regimens for large bowel cancer. |
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Authors:
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T M Morgan |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biometrics Volume: 43 ISSN: 0006-341X ISO Abbreviation: Biometrics Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-03-24 Completed Date: 1988-03-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370625 Medline TA: Biometrics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 903-12 Citation Subset: IM |
Affiliation:
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Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill 27514. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biometry Clinical Trials as Topic / methods* Follow-Up Studies Humans Research Design Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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5-P30-CA12197-11/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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