Document Detail

Nonparametric estimation of duration of accrual and total study length for clinical trials.
MedLine Citation:
PMID:  3427175     Owner:  NLM     Status:  MEDLINE    
Nonparametric estimates for all possible values of accrual duration and total study length required to achieve a specified power and level of significance are given assuming a proportional hazards model comparing two treatment groups. Based on data from a previous representative clinical trial, the nonparametric maximum likelihood estimate of total study length and its asymptotic distribution are derived as functions of accrual duration. An example using this technique is given for designing a clinical trial comparing two adjuvant chemotherapy regimens for large bowel cancer.
T M Morgan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biometrics     Volume:  43     ISSN:  0006-341X     ISO Abbreviation:  Biometrics     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-03-24     Completed Date:  1988-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370625     Medline TA:  Biometrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  903-12     Citation Subset:  IM    
Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill 27514.
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MeSH Terms
Clinical Trials as Topic / methods*
Follow-Up Studies
Research Design
Time Factors
Grant Support
5-P30-CA12197-11/CA/NCI NIH HHS

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