| Nonoxidative modifications of lipoproteins in atherogenesis. | |
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MedLine Citation:
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PMID: 10448519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The key initiating event in atherosclerosis is the retention of plasma lipoproteins in the subendothelial matrix. Subsequently, a series of biological responses to this retained material leads to specific molecular and cellular processes that promote lesion formation. There is considerable evidence that many of these biological responses, notably macrophage cholesteryl ester loading (foam cell formation), require subendothelial modification of the retained lipoproteins. Oxidation of lipoproteins is one such modification that likely occurs in vivo and promotes certain atherogenic events, but oxidation cannot explain all aspects of atherogenesis, including certain elements of macrophage foam cell formation. For this reason, there has been renewed interest in other modifications of lipoproteins that may be important in atherogenesis. This review addresses five such lipoprotein modifications, namely aggregation, glycation, immune complex formation, proteoglycan complex formation, and conversion to cholesterol-rich liposomes. The focus is on the evidence that these modifications occur in atherosclerotic lesions and on the potential role of these modified lipoproteins in atherogenesis, with an emphasis on macrophage foam cell formation. |
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Authors:
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I Tabas |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Annual review of nutrition Volume: 19 ISSN: 0199-9885 ISO Abbreviation: Annu. Rev. Nutr. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-10-04 Completed Date: 1999-10-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8209988 Medline TA: Annu Rev Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 123-39 Citation Subset: IM |
Affiliation:
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Department of Medicine and Anatomy, Columbia University, New York, New York 10032, USA. iat1@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigen-Antibody Complex Arteriosclerosis / blood* Cholesterol / blood Glycosylation Humans Lipoproteins / blood*, chemistry Lipoproteins, LDL / blood, chemistry Liposomes Proteoglycans |
| Grant Support | |
ID/Acronym/Agency:
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HL-56984/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 0/Lipoproteins; 0/Lipoproteins, LDL; 0/Liposomes; 0/Proteoglycans; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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