Document Detail

Nonnoradrenergic mechanism of reflex cutaneous vasoconstriction in men.
MedLine Citation:
PMID:  11247759     Owner:  NLM     Status:  MEDLINE    
We tested for a nonnoradrenergic mechanism of reflex cutaneous vasoconstriction with whole body progressive cooling in seven men. Forearm sites (<1 cm(2)) were pretreated with: 1) yohimbine (Yoh; 5 mM id) to antagonize alpha-adrenergic receptors, 2) Yoh plus propranolol (5 mM Yoh-1 mM PR id) to block alpha- and beta-adrenergic receptors, 3) iontophoretic application of bretylium tosylate (BT) to block all sympathetic vasoconstrictor nerve effects, or 4) intradermal saline. Skin blood flow was measured by laser Doppler flowmetry and arterial pressure by finger photoplethysmography; cutaneous vascular conductance (CVC) was indexed as the ratio of the two. Whole body skin temperature (T(SK)) was controlled at 34 degrees C (water-perfused suit) for 10 min and then lowered to 31 degrees C over 15 min. During cooling, vasoconstriction was blocked at BT sites (P > 0.05). CVC at saline sites fell significantly beginning at T(SK) of 33.4 +/- 0.01 degrees C (P <0.05). CVC at Yoh-PR sites was significantly reduced beginning at TSK of 33.0 +/- 0.01 degrees C (P < 0.05). After cooling, iontophoretic application of norepinephrine (NE) confirmed blockade of adrenergic receptors by Yoh-PR. Because the effects of NE were blocked at sites showing significant reflex vasoconstriction, a nonnoradrenergic mechanism in human skin is indicated, probably via a sympathetic cotransmitter.
D P Stephens; K Aoki; W A Kosiba; J M Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  280     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-15     Completed Date:  2001-04-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1496-504     Citation Subset:  IM    
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology*
Blood Pressure
Forearm / blood supply
Idazoxan / pharmacology
Laser-Doppler Flowmetry
Norepinephrine / pharmacology*
Propranolol / pharmacology
Receptors, Adrenergic, alpha / physiology*
Receptors, Adrenergic, beta / physiology
Regional Blood Flow / drug effects,  physiology
Skin / blood supply*
Skin Temperature / drug effects,  physiology*
Vasoconstriction / drug effects,  physiology*
Yohimbine / pharmacology*
Grant Support
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 146-48-5/Yohimbine; 51-41-2/Norepinephrine; 525-66-6/Propranolol; 79944-58-4/Idazoxan

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