Document Detail


Nonmyeloablative conditioning followed by hematopoietic cell allografting and donor lymphocyte infusions for patients with metastatic renal and breast cancer.
MedLine Citation:
PMID:  12010834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The feasibility and toxicity of allogeneic stem cell transplantation after nonmyeloablative conditioning including thiotepa, fludarabine, and cyclophosphamide have been investigated in 6 patients with breast cancer and 7 patients with renal cell cancer. The program included the use of escalating doses of donor lymphocyte infusions (DLI) and/or interferon alpha (IFNalpha) for patients showing no tumor response and no graft-versus-host disease (GVHD). Patients were at high risk of transplant-related mortality (TRM) because of age, advanced stage, and previous treatments. We observed a partial remission in 4 renal cancer and in 2 breast cancer patients (one at the molecular level in the bone marrow), occurring after cyclosporine withdrawal or after DLI and/or IFNalpha. All the responses were accompanied by the occurrence of acute GVHD. We conclude that reduced-intensity allogeneic stem cell transplantation is a feasible procedure in renal and breast cancer, and that the exploitation of graft-versus-tumor effect after DLI is a promising finding.
Authors:
Marco Bregni; Anna Dodero; Jacopo Peccatori; Alessandra Pescarollo; Massimo Bernardi; Isabella Sassi; Claudia Voena; Alberto Zaniboni; Claudio Bordignon; Paolo Corradini
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood     Volume:  99     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4234-6     Citation Subset:  AIM; IM    
Affiliation:
Bone Marrow Transplant Unit and Gene Therapy Program and the Division of Pathology, Istituto H San Raffaele, Milano, Italy. marco.bregni@hsr.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Breast Neoplasms / pathology,  therapy*
Carcinoma, Renal Cell / therapy*
Female
Hematopoietic Stem Cell Transplantation*
Humans
Kidney Neoplasms / pathology,  therapy*
Lymphocyte Transfusion*
Male
Middle Aged
Neoplasm Metastasis
Nuclear Family
Platelet Transfusion*
Tissue Donors
Transplantation, Homologous / immunology*,  methods
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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