| Nonmyeloablative conditioning followed by hematopoietic cell allografting and donor lymphocyte infusions for patients with metastatic renal and breast cancer. | |
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MedLine Citation:
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PMID: 12010834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The feasibility and toxicity of allogeneic stem cell transplantation after nonmyeloablative conditioning including thiotepa, fludarabine, and cyclophosphamide have been investigated in 6 patients with breast cancer and 7 patients with renal cell cancer. The program included the use of escalating doses of donor lymphocyte infusions (DLI) and/or interferon alpha (IFNalpha) for patients showing no tumor response and no graft-versus-host disease (GVHD). Patients were at high risk of transplant-related mortality (TRM) because of age, advanced stage, and previous treatments. We observed a partial remission in 4 renal cancer and in 2 breast cancer patients (one at the molecular level in the bone marrow), occurring after cyclosporine withdrawal or after DLI and/or IFNalpha. All the responses were accompanied by the occurrence of acute GVHD. We conclude that reduced-intensity allogeneic stem cell transplantation is a feasible procedure in renal and breast cancer, and that the exploitation of graft-versus-tumor effect after DLI is a promising finding. |
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Authors:
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Marco Bregni; Anna Dodero; Jacopo Peccatori; Alessandra Pescarollo; Massimo Bernardi; Isabella Sassi; Claudia Voena; Alberto Zaniboni; Claudio Bordignon; Paolo Corradini |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood Volume: 99 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-05-15 Completed Date: 2002-07-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 4234-6 Citation Subset: AIM; IM |
Affiliation:
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Bone Marrow Transplant Unit and Gene Therapy Program and the Division of Pathology, Istituto H San Raffaele, Milano, Italy. marco.bregni@hsr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Breast Neoplasms / pathology, therapy* Carcinoma, Renal Cell / therapy* Female Hematopoietic Stem Cell Transplantation* Humans Kidney Neoplasms / pathology, therapy* Lymphocyte Transfusion* Male Middle Aged Neoplasm Metastasis Nuclear Family Platelet Transfusion* Tissue Donors Transplantation, Homologous / immunology*, methods Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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