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Nonmurine animal models of food allergy.
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MedLine Citation:
PMID:  12573913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food allergy can present as immediate hypersensitivity [manifestations mediated by immunoglobulin (Ig)E], delayed-type hypersensitivity (reactions associated with specific T lymphocytes), and inflammatory reactions caused by immune complexes. For reasons of ethics and efficacy, investigations in humans to determine sensitization and allergic responses of IgE production to innocuous food proteins are not feasible. Therefore, animal models are used a) to bypass the innate tendency to develop tolerance to food proteins and induce specific IgE antibody of sufficient avidity/affinity to cause sensitization and upon reexposure to induce an allergic response, b) to predict allergenicity of novel proteins using characteristics of known food allergens, and c) to treat food allergy by using immunotherapeutic strategies to alleviate life-threatening reactions. The predominant hypothesis for IgE-mediated food allergy is that there is an adverse reaction to exogenous food proteins or food protein fragments, which escape lumen hydrolysis, and in a polarized helper T cell subset 2 (Th2) environment, immunoglobulin class switching to allergen-specific IgE is generated in the immune system of the gastrointestinal-associated lymphoid tissues. Traditionally, the immunologic characterization and toxicologic studies of small laboratory animals have provided the basis for development of animal models of food allergy; however, the natural allergic response in large animals, which closely mimic allergic diseases in humans, can also be useful as models for investigations involving food allergy.
Authors:
Ricki M Helm; Richard W Ermel; Oscar L Frick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  111     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-07     Completed Date:  2003-05-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Division of Allergy/Immunology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, USA. HelmRickiM@uams.edu
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology
Animals
Animals, Laboratory
Animals, Newborn
Disease Models, Animal*
Dogs
Food Hypersensitivity / physiopathology*,  veterinary
Humans
Hydrolysis
Immunoglobulin E / immunology
Inflammation
Organisms, Genetically Modified
Proteins / adverse effects,  immunology*
Swine
Chemical
Reg. No./Substance:
0/Allergens; 0/Proteins; 37341-29-0/Immunoglobulin E
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 2 Year: 2003
Volume: 111 Issue: 2
First Page: 239 Last Page: 244
ID: 1241358
PubMed Id: 12573913

Nonmurine animal models of food allergy.
Ricki M Helm
Richard W Ermel
Oscar L Frick
Department of Pediatrics, Division of Allergy/Immunology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, USA. HelmRickiM@uams.edu


Article Categories:
  • Research Article


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