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Nonmotor Symptoms in Patients with PARK2 Mutations.
MedLine Citation:
PMID:  21317980     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Decreased (123)I-meta-iodobenzylguanidine (MIBG) uptake in MIBG myocardial scintigraphy, olfactory dysfunction, and rapid eye movement (REM) sleep behavior disorder (RBD) are considered useful early indicators of Parkinson disease. We investigated whether patients with PARK2 mutations exhibited myocardial sympathetic abnormalities using MIBG scintigraphy, olfactory dysfunction using the Sniffin' Sticks olfactory test, and RBD using polysomnography. None of the examined patients had RBD, and all except 1 patient exhibited an increase in the olfactory threshold. Moreover, one of the oldest patients exhibited impairment in identification and discrimination. Of 12 patients with PARK2 mutations, 4 patients, who were older than patients without abnormal uptake, exhibited decreased MIBG uptake. The results obtained in this study suggest that some patients with PARK2 mutations have increased thresholds of olfactory function and myocardial sympathetic dysfunction as nonmotor symptoms.
Authors:
Asako Yoritaka; Yumi Shimo; Yasushi Shimo; Yuichi Inoue; Hiroyo Yoshino; Nobutaka Hattori
Publication Detail:
Type:  Journal Article     Date:  2011-01-13
Journal Detail:
Title:  Parkinson's disease     Volume:  2011     ISSN:  2042-0080     ISO Abbreviation:  Parkinsons Dis     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-07-14     Revised Date:  2011-07-25    
Medline Journal Info:
Nlm Unique ID:  101539877     Medline TA:  Parkinsons Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  473640     Citation Subset:  -    
Affiliation:
Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
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