Document Detail


Nonmolecular treatment for muscular dystrophies.
MedLine Citation:
PMID:  16155433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: This review highlights emerging evidence on the management of patients with muscular dystrophies.
RECENT FINDINGS: New diagnostic modalities based on muscle biopsy and DNA analysis mean that diagnoses within the heterogeneous group of muscular dystrophies can be much more precise; also, as the phenotypes associated with these different disorders are clarified, new management implications can be recognized. At the same time, the spread of evidence based medicine into this area has led to an increase in clinical trial activity and the development of evidence based guidelines. Because many if not all muscular dystrophies are multisystem disorders, these guidelines relate not only to the limited number of interventions aimed at improving strength but also to the management of potentially life threatening complications.
SUMMARY: Because specific diagnoses carry specific management implications in many areas for these hitherto rather neglected disorders, a more proactive approach to patients with muscular dystrophies is needed. Complications involving, for example, the cardiovascular, respiratory and gastrointestinal systems may need to be sought and actively managed, whereas caution for complications of anaesthesia and other interventions may also be necessary. However, areas remain where there is little evidence from which practice guidelines can be developed and these will need to be addressed with well planned clinical trials.
Authors:
Kate Bushby; Volker Straub
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  18     ISSN:  1350-7540     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-12     Completed Date:  2006-03-14     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  511-8     Citation Subset:  IM    
Affiliation:
Newcastle upon Tyne Muscle Centre, Institute of Human Genetics, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK. kate.bushby@ncl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Anesthesia
Cardiomyopathies / etiology
Drug Therapy
Gastrointestinal Diseases / etiology
Humans
Muscular Dystrophies / complications,  diagnosis,  therapy*
Pain / etiology
Physical Therapy Specialty
Respiration

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