Document Detail

Nonlinear temporal integration of brain stimulation reward.
MedLine Citation:
PMID:  22122150     Owner:  NLM     Status:  MEDLINE    
A good deal is known about psychological factors that contribute to reward value, but very little is known about how reward is computed in the brain. Integration in the circuit for brain stimulation reward may provide a simple model system. Parametric studies have favored the idea that the integration is linear, although a few have suggested that it involves adaptation. However, these studies have generally not focused on relevance to psychological factors such as temporal discounting of reward. To begin to address these issues, I gave rats a choice between a simple train of 2 seconds of stimulation at a uniform frequency and a compound train of 1 second of stimulation at either 50, 150, or 250 Hz immediately followed by 1 second of stimulation at 50, 150, or 250 Hz, for a total of nine compound trains. For each compound train, the frequency of the simple train was varied until a level was found that produced indifference. The order of the frequencies was important, with Hi-Lo compound stimulation having a higher matching frequency than the symmetrical Lo-Hi. Furthermore, there was an interaction between the first and second frequencies, with the second frequency counting less when the first frequency was high. The results could be fit by computational models incorporating the ideas of either (a) adaptation or (b) temporal discounting and a power function psychological scale. These results suggest that integration in the brain stimulation reward system is nonlinear, and involves either adaptation or temporal discounting of reward value.
Robert D Hawkins
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  125     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-29     Completed Date:  2012-08-20     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  892-9     Citation Subset:  IM    
Copyright Information:
PsycINFO Database Record (c) 2011 APA, all rights reserved.
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MeSH Terms
Adaptation, Physiological / physiology
Brain / physiology*
Choice Behavior / physiology*
Nonlinear Dynamics*
Rats, Sprague-Dawley
Self Stimulation / physiology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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