Document Detail


Nonlinear pressure-flow relationships for passive microfluidic valves.
MedLine Citation:
PMID:  19704985     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
An analytical solution is presented for the nonlinear pressure-flow relationship of deformable passive valves, which are formed by bonding a deformable film over etched channels separated by a weir. A fluidic pathway connecting the channels is opened when the upstream pressure creates a tunnel along a predefined narrow strip where the film is not bonded to the weir. When the width of the strip is comparable to the inlet channel width, the predicted closed-form pressure-flow rate relationship is in excellent agreement with experiments, which determine pressures by measuring film deflections for prescribed flow rates. The validated closed-form models involve no fitting parameters, and provide the foundation to design passive diodes with specific nonlinear pressure-flow characteristics.
Authors:
Erkin Seker; Daniel C Leslie; Hossein Haj-Hariri; James P Landers; Marcel Utz; Matthew R Begley
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Publication Detail:
Type:  Journal Article     Date:  2009-06-24
Journal Detail:
Title:  Lab on a chip     Volume:  9     ISSN:  1473-0197     ISO Abbreviation:  -     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  2691-7     Citation Subset:  -    
Affiliation:
Center for Microsystems for the Life Sciences, University of Virginia, Charlottesville, VA 22902, USA.
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