| Nonlinear cross-frequency interactions in primary auditory cortex spectrotemporal receptive fields: a Wiener-Volterra analysis. | |
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MedLine Citation:
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PMID: 20072806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of nonlinear interactions between different sound frequencies on the responses of neurons in primary auditory cortex (AI) have only been investigated using two-tone paradigms. Here we stimulated with relatively dense, Poisson-distributed trains of tone pips (with frequency ranges spanning five octaves, 16 frequencies /octave, and mean rates of 20 or 120 pips /s), and examined within-frequency (or auto-frequency) and cross-frequency interactions in three types of AI unit responses by computing second-order "Poisson-Wiener" auto- and cross-kernels. Units were classified on the basis of their spectrotemporal receptive fields (STRFs) as "double-peaked", "single-peaked" or "peak-valley". Second-order interactions were investigated between the two bands of excitatory frequencies on double-peaked STRFs, between an excitatory band and various non-excitatory bands on single-peaked STRFs, and between an excitatory band and an inhibitory sideband on peak-valley STRFs. We found that auto-frequency interactions (i.e., those within a single excitatory band) were always characterized by a strong depression of (first-order) excitation that decayed with the interstimulus lag up to approximately 200 ms. That depression was weaker in cross-frequency compared to auto-frequency interactions for approximately 25% of dual-peaked STRFs, evidence of "combination sensitivity" for the two bands. Non-excitatory and inhibitory frequencies (on single-peaked and peak-valley STRFs, respectively) typically weakly depressed the excitatory response at short interstimulus lags (<50 ms), but weakly facilitated it at longer lags ( approximately 50-200 ms). Both the depression and especially the facilitation were stronger for interactions with inhibitory frequencies rather than just non-excitatory ones. Finally, facilitation in single-peaked and peak-valley units decreased with increasing stimulus density. Our results indicate that the strong combination sensitivity and cross-frequency facilitation suggested by previous two-tone-paradigm studies are much less pronounced when using more temporally-dense stimuli. |
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Authors:
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Martin Pienkowski; Jos J Eggermont |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-14 |
Journal Detail:
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Title: Journal of computational neuroscience Volume: 28 ISSN: 1573-6873 ISO Abbreviation: J Comput Neurosci Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9439510 Medline TA: J Comput Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 285-303 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Action Potentials / physiology Animals Auditory Cortex / physiology* Auditory Pathways / physiology* Auditory Perception / physiology Cats Electrophysiology Models, Neurological Neurons / physiology* Nonlinear Dynamics Signal Processing, Computer-Assisted |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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