Document Detail


Nonlinear scaling of surface water diffusion with bulk water viscosity of crowded solutions.
MedLine Citation:
PMID:  23347324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The translational hydration dynamics within 0.5-1.5 nm of the surface of a DPPC liposome, a model biomacromolecular surface, is analyzed by the recently developed Overhauser dynamic nuclear polarization (ODNP) technique. We find that dramatic changes to the bulk solvent cause only weak changes in the surface hydration dynamics. Specifically, both a >10-fold increase in bulk viscosity and the restriction of diffusion by confinement on a multiple nm length-scale change the local translational diffusion coefficient of the surface water surrounding the lipid bilayer by <2.5-fold. By contrast, previous ODNP studies have shown that changes to the biomacromolecular surface induced by folding, binding, or aggregation can cause local hydration dynamics to vary by factors of up to 30. We suggest that the surface topology and chemistry at the ≤1.5 nm scale, rather than the characteristics of the solvent, nearly exclusively determine the macromolecule's surface hydration dynamics.
Authors:
John M Franck; John A Scott; Songi Han
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-03-11
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  135     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-20     Completed Date:  2013-09-09     Revised Date:  2014-10-25    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4175-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
1,2-Dipalmitoylphosphatidylcholine / analogs & derivatives*,  chemistry
Diffusion
Liposomes / chemistry*
Solutions / chemistry
Surface Properties
Viscosity
Water / chemistry*
Grant Support
ID/Acronym/Agency:
DP2 OD008702/OD/NIH HHS
Chemical
Reg. No./Substance:
0/Liposomes; 0/Solutions; 059QF0KO0R/Water; 2644-64-6/1,2-Dipalmitoylphosphatidylcholine; 319X2NFW0A/colfosceril palmitate
Comments/Corrections

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