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Nonleukemic myeloid sarcoma of the liver: a case report and review of literature.
MedLine Citation:
PMID:  21484146     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Myeloid sarcoma (MS) is a neoplasm of immature granulocytes, monocytes, or both involving extramedullary sites. MS with no evidence of leukemia (nonleukemic MS) is very rare and the initial diagnosis can be difficult. This report describes an unusual case of nonleukemic MS of the liver in a 16-year-old patient presenting as debilitating hepatomegaly. A liver biopsy revealed diffuse infiltration by neoplastic cells of myeloid lineage (CD68, myeloperoxidase). A bone marrow biopsy showed no evidence of medullary involvement. The patient subsequently developed heart failure. Autopsy revealed infiltration of most organs by neoplastic cells but failed to identify abnormal myeloid cells in bone marrow.
Authors:
Xiao-Feng Hang; Hai-Guang Xin; Lei Wang; Wen-Sheng Xu; Jun-Xue Wang; Wu Ni; Xiong Cai; Rui-Qi Zhang
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Publication Detail:
Type:  Journal Article     Date:  2011-01-15
Journal Detail:
Title:  Hepatology international     Volume:  5     ISSN:  1936-0541     ISO Abbreviation:  Hepatol Int     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-10     Completed Date:  2011-07-14     Revised Date:  2011-08-01    
Medline Journal Info:
Nlm Unique ID:  101304009     Medline TA:  Hepatol Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  747-50     Citation Subset:  -    
Affiliation:
Department of Infectious Diseases, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
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