Document Detail


Nonionic contrast use in cardiac angiography.
MedLine Citation:
PMID:  8282503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This article reviews the safety profile of nonionic versus ionic contrast media, focussing on those aspects specific to the cardiac catheterization laboratory.
DATA ANALYZED: Comparative electrophysiologic and hemodynamic effects, nephrotoxicity, thrombosis-related complications, and other possible adverse effects are discussed. Volume limitations and approaches to efficient use of nonionic agents also are considered.
RESULTS: Previous investigations indicate that cardiac electrophysiologic and hemodynamic effects are less with nonionic contrast media than with conventional high-osmolar ionic agents. Studies assessing potential adverse reactions suggest an advantage with nonionics, compared with high-osmolar ionic agents, mostly regarding reduction in mild-to-moderate adverse events. In general, studies on the risk of nephrotoxicity among cardiac angiography patients demonstrate no difference between nonionic and ionic contrast or a slight beneficial effect with nonionics among those with pre-existing renal dysfunction. There is no convincing evidence for an increased incidence of thrombosis-related events with nonionic agents during coronary angiography and data regarding nonionic contrast-related thrombosis in patients undergoing coronary angioplasty are conflicting.
CONCLUSIONS: At the present time, there is no justification for avoiding nonionic contrast agents based on the risk of thrombosis. Research findings on the effect of contrast volume are also inconclusive.
Authors:
J A Hill
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Investigative radiology     Volume:  28 Suppl 5     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-17     Completed Date:  1994-02-17     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S48-53; discussion S54     Citation Subset:  IM    
Affiliation:
Division of Cardiology, University of Florida College of Medicine, Gainesville.
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Balloon, Coronary
Cardiac Catheterization
Contrast Media / adverse effects*
Coronary Angiography*
Electrocardiography / drug effects
Hemodynamics / drug effects
Humans
Kidney / drug effects
Radiography, Interventional
Thrombosis / chemically induced
Chemical
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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