Document Detail

Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans.
MedLine Citation:
PMID:  18006869     Owner:  NLM     Status:  MEDLINE    
Ten healthy human volunteers were subjected to progressive lower body negative pressure (LBNP) to the onset of cardiovascular collapse to compare the response of noninvasively determined skin and fat corrected deep muscle oxygen saturation (SmO2) and pH to standard hemodynamic parameters for early detection of imminent hemodynamic instability. Muscle SmO2 and pH were determined with a novel near infrared spectroscopic (NIRS) technique. Heart rate (HR) was measured continuously via ECG, and arterial blood pressure (BP) and stroke volume (SV) were obtained noninvasively via Finometer and impedance cardiography on a beat-to-beat basis. SmO2 and SV were significantly decreased during the first LBNP level (-15 mmHg), whereas HR and BP were late indicators of impending cardiovascular collapse. SmO2 declined in parallel with SV and inversely with total peripheral resistance, suggesting, in this model, that SmO2 is an early indicator of a reduction in oxygen delivery through vasoconstriction. Muscle pH decreased later, suggesting an imbalance between delivery and demand. Spectroscopic determination of SmO2 is noninvasive and continuous, providing an early indication of impending cardiovascular collapse resulting from progressive reduction in central blood volume.
Babs R Soller; Ye Yang; Olusola O Soyemi; Kathy L Ryan; Caroline A Rickards; J Matthias Walz; Stephen O Heard; Victor A Convertino
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-11-15
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  104     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-04-04     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  475-81     Citation Subset:  IM    
Dept. of Anesthesiology, UMass Medical School, 55 Lake Ave North, Worcester, MA 01655, USA.
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MeSH Terms
Adipose Tissue / metabolism
Blood Pressure
Blood Volume
Heart Rate
Hydrogen-Ion Concentration
Hypovolemia / diagnosis*,  metabolism,  physiopathology
Lower Body Negative Pressure
Models, Cardiovascular
Muscle, Skeletal / metabolism*
Oxygen / blood,  metabolism*
Oxygen Consumption*
Skin / metabolism
Spectrophotometry, Infrared*
Stroke Volume
Time Factors
Vascular Resistance
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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