Document Detail

Noninvasive respiratory muscle aids during PEG placement in ALS patients with severe ventilatory impairment.
MedLine Citation:
PMID:  20659743     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the efficacy of noninvasive ventilation (NIV) and mechanically assisted cough (MAC) to avoid respiratory complications related to PEG placement in ALS patients with SVMI.
MATERIAL AND METHODS: Prospective study including ALS patients who had chosen to have PEG placement timed by swallowing dysfunction with the aid of NIV and MAC if needed. PEG was carried out under volume-cycled NIV through a nasal mask. MAC was applied prior to and at the end of the procedure.
RESULTS: Thirty ALS patients (60.43±12.03years) were included. Prior to PEG placement: BMI 25.0±4.6kg/m(2), ALSRFS-R 19.5±5.0, Norris bulbar sub-score 15.1±6.6, %FVC 35.9±18.1%, PCF 2.3±1.2L/s, PImax -35.6±24.6cmH(2)O, and PEmax 40.5±23.9cmH(2)O. Three patients had PEG placement under tracheotomy ventilation because NIV SpO(2) was below 88%. No patient died during the procedure nor did any have respiratory complications. Survival at 1month was 100%.
CONCLUSION: Respiratory support provided by volume-cycled NIV and MAC permits successful PEG placement in most ALS patients with SVMI.
Jesús Sancho; Emilio Servera; Eusebi Chiner; Pilar Bañuls; Elia Gómez-Merino; José N Sancho-Chust; Julio Marín
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-24
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  297     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  55-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Respiratory Care Unit, Respiratory Medicine Department, Hospital Clínico Universitario, Fundación para la Investigación HCUV-INCLIVA, Valencia, Spain; Universitat de Valencia, Spain.
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MeSH Terms
Amyotrophic Lateral Sclerosis / surgery*
Body Mass Index
Cough / etiology
Gastroscopy / adverse effects*
Gastrostomy / adverse effects*
Middle Aged
Prospective Studies
Respiration Disorders / etiology*,  pathology
Respiratory Function Tests / methods
Respiratory Muscles / pathology,  surgery
Tracheostomy / adverse effects*
Vital Capacity / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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