Document Detail

Noninvasive quantification of muscle oxygen in subjects with and without claudication.
MedLine Citation:
PMID:  9021624     Owner:  NLM     Status:  MEDLINE    
The disabling pain of intermittent claudication (IC) arises from oxygen deprivation in the lower limbs during walking. Measurement of the oxygen deficiency within the limb tissue now appears possible with recently expanded understanding of the photon transport through tissue for photons in the visible and near infrared range. Noninvasive measurement consists of preferentially measuring photons that have traveled more deeply into limb tissues and that, therefore, may reach locations of ischemic tissue. Oxygen measurements appear to be possible up to a depth approaching 1.5 cm beneath the surface of the skin. The present study reports on data acquired from the limbs of 11 subjects with IC and 12 subjects without IC. The subjects with IC are patients with clinical findings of claudication based upon segmental Doppler pressure profiles and subjective reports by the patient of pain during exercise. The subjects without IC are individuals with no prior history of ischemic vascular disease. The results consist of photon reflectance measurements at red and infrared wavelengths (approximately 660 nm and 880 nm respectively) taken before, during, and after exercise. Infrared reflectance indices are plotted as well as oxygenation indices generated from combining red and infrared reflectances. A compilation of exercise data shows responses that are generally consistent with the expected physiological responses to mild exercise in subjects with and without IC. We anticipate that the findings of this study may lead to an objective noninvasive testing procedure for measuring the ischemic and exercise-induced changes in muscle oxygenation in the presence of claudication. If the testing of ischemic hypoxia continues to show consistency and accuracy in determining the disability of the subjects with IC, future studies can more effectively test modes of conservative management, such as cessation of smoking, alternative exercise regimens, weight loss, and alternative pharmacological agents.
B Y Lee; E Ostrander; M Karmakar; L Frenkel; B Herz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of rehabilitation research and development     Volume:  34     ISSN:  0748-7711     ISO Abbreviation:  J Rehabil Res Dev     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-17     Completed Date:  1997-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8410047     Medline TA:  J Rehabil Res Dev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-51     Citation Subset:  IM    
Department of Surgery, VA Medical Center, Castle Point, NY 12511, USA.
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MeSH Terms
Exercise / physiology
Infrared Rays / diagnostic use*
Intermittent Claudication / diagnosis*,  etiology,  physiopathology
Muscle, Skeletal / blood supply
Oxygen Consumption / physiology*
Peripheral Vascular Diseases / complications,  diagnosis*
Reference Values
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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