Document Detail

Noninvasive prediction of hyaline membrane disease: an optimized classification of sonographic placental maturation.
MedLine Citation:
PMID:  3890546     Owner:  NLM     Status:  MEDLINE    
Accurate prediction of fetal pulmonary maturity by means of a less invasive procedure than amniocentesis would be desirable. Sonographic diagnosis of a Grade III placenta has been reported to be an excellent predictor of fetal lung maturity. The standard classification of placental grading assigns grade according to the most advanced portion of the placenta. Using this classification, we studied 230 patients. In 80 pregnancies with Grade III placenta, three of the neonates developed respiratory distress syndrome. With reclassification of the placentas as immature, (no Grade III areas), intermediate, (only a portion of the placenta being Grade III), or mature, (Grade III placenta throughout), it was found that no neonatal hyaline membrane disease occurred in the 41 pregnancies with mature placentas, whereas 12% of the neonates in the immature group and 8% in the intermediate group developed hyaline membrane disease. These findings suggest that when sonographic examination of the placenta shows both Grade III and non-Grade III sections, there is still a risk for an immature amniotic fluid lecithin/sphingomyelin ratio and neonatal hyaline membrane disease. The placentas should be considered mature only when Grade III changes are present in all sections examined by ultrasound.
G M Kazzi; T L Gross; R J Sokol; S N Kazzi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  152     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-03     Completed Date:  1985-07-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  213-9     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / metabolism
Fetal Organ Maturity
Gestational Age
Hyaline Membrane Disease / diagnosis*,  physiopathology
Infant, Newborn
Phospholipids / metabolism
Placenta / pathology,  physiology*
Reg. No./Substance:

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