Document Detail

Noninvasive positive pressure ventilation in patients with perioperative negative pressure pulmonary edema.
MedLine Citation:
PMID:  20221646     Owner:  NLM     Status:  MEDLINE    
Negative pressure pulmonary edema (NPPE) is a noncardiogenic pathological process that is treated with invasive ventilation via a tracheal tube. To investigate the feasibility and safety of noninvasive positive pressure ventilation (NPPV) as an alternative treatment for NPPE, we retrospectively reviewed charts of 15 perioperative NPPE patients. Eight patients were treated by NPPV and 7 were treated by invasive ventilation. Patient characteristics, duration of NPPV, duration of intensive care unit (ICU) stay, and maximum airway pressure were investigated for the NPPV-treated patients. All patients treated by NPPV had a patent airway after complete relief of the airway obstruction and recovered from NPPE symptoms within one postoperative day. Arterial blood gas analysis showed a significant improvement in the PaO(2)/FiO(2) ratio from 132 + or - 30 mmHg in the operating room to 282 + or - 77 mmHg at discontinuation of NPPV. Serious complications, such as ventilator-associated pneumonia or aspiration pneumonia, did not occur, and intubation was not required for any patient. Favorable outcomes in these cases suggest that NPPV could be a feasible and safe alternative for treating NPPE if the patency of the airway is restored.
Masayuki Furuichi; Shinhiro Takeda; Shinji Akada; Hidetaka Onodera; Yuko Yoshida; Keiko Nakazato; Atsuhiro Sakamoto
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Publication Detail:
Type:  Journal Article     Date:  2010-03-11
Journal Detail:
Title:  Journal of anesthesia     Volume:  24     ISSN:  1438-8359     ISO Abbreviation:  J Anesth     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8905667     Medline TA:  J Anesth     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  464-8     Citation Subset:  IM    
Department of Anesthesiology, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
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MeSH Terms
Acidosis / complications
Blood Gas Analysis
Hydrogen-Ion Concentration
Intensive Care
Middle Aged
Oxygen / blood
Perioperative Care*
Positive-Pressure Respiration* / adverse effects
Pulmonary Edema / diagnosis,  therapy*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:

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